Strategy for treatment of septic shock by poly (ADP-ribose) synthetase inhibitor
Strategy for treatment of septic shock by poly (ADP-ribose) synthetase inhibitor
批准号:
18591978
负责人:
MITAKA Chieko
金额:
$2.74万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2009
中文摘要
为了探讨脓毒性休克的治疗策略,我们在大鼠内毒素休克模型中给予3-氨基苯甲酰胺,聚(ADP-核糖)合成酶抑制剂。3-氨基苯甲酰胺降低全身炎症反应并改善血流动力学。提示聚ADP核糖合成酶在感染性休克发病机制中起重要作用。
英文摘要
To investigate a strategy for treatment of septic shock, we administered 3-aminobenzamide, poly (ADP-ribose) synthetase inhibitor, in rat endotoxic shock model. 3-aminobenzamide reduced systemic inflammatory response and improved hemodynamics. These findings suggest that poly (ADP-ribose) synthetase plays an important role in mechanism of septic shock.
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Effect of human natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair
人钠尿肽对腹主动脉瘤修复术患者肾功能的影响
DOI:
--
发表时间:
2008
期刊:
Crit Care Med 30
影响因子:
--
作者:
[Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T.]
通讯作者:
Imai T.
Beneficial effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair.
人心房钠尿肽对接受腹主动脉瘤修复术的患者肾功能的有益影响。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Hori K, et. al., Chieko Mitaka]
通讯作者:
Chieko Mitaka
DOI:
10.1097/shk.0b013e3181a2a978
发表时间:
2009-11-01
期刊:
SHOCK
影响因子:
3.1
作者:
[Mitaka, Chieko, Tsuchida, Naoki, Sasaki, Sei]
通讯作者:
Sasaki, Sei
Polynyxin B-immobilized fiber column hemoperfusion has the possibility to reduce endothelial activation in patients with septic shock. Effect of endotoxin adsorption therapy on hemodynamics, procaicitonin and C-reactive protein in patients with septic sho
多粘菌素 B 固定纤维柱血液灌流有可能减少感染性休克患者的内皮活化。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Mitaka C, Fuji Y, Nakajma Y, Kawada K, lmai T Mitaka C, Tsuchiya K, Kawada K, Nakajima Y, Imai T]
通讯作者:
Imai T
Effects of human atria lnatriuretic peptide on renal function in patients under going abdominal aortic aneurysm repair
人心钠肽对腹主动脉瘤修复术患者肾功能的影响
DOI:
--
发表时间:
2008
期刊:
Crit Care Med 36
影响因子:
--
作者:
[Mitakac, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T]
通讯作者:
Imai T
共 6 条
Mechanism of protective effects of atrial natriuretic peptide on acute kidney injury
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批准号:22592010
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.41万
-
财政年份:2010
-
负责人:MITAKA Chieko
-
依托单位:
Treatment strategy of septic shock by inhibition of transcription factor, NF-kB
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批准号:14571423
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.18万
-
财政年份:2002
-
负责人:MITAKA Chieko
-
依托单位:
Relationship between endothelin and organ dysfunction in SIRS
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批准号:09671543
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1997
-
负责人:MITAKA Chieko
-
依托单位:
Effects of N^G-nitro-L-arginine on hemodynamic changes in endotoxin shock
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批准号:05671252
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.47万
-
财政年份:1993
-
负责人:MITAKA Chieko
-
依托单位:
海外基金