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Development of cellular adhesion control type dental implant coated by biocompatible polymer

生物相容性聚合物涂层细胞粘附控制型牙种植体的开发

基本信息

批准号：
18592112
负责人：
TOMIZUKA Ken
金额：
$ 2.24万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592112/
关键词：
biocompatibility MPC polymer titanium cell adhesion チタン合金

项目摘要

It is clarified that MPC polymer, that has the phosphorus lipid polarity radical, coated to the surface of material control the cell and the protein adhesion. As a result, the biocompatibility and the blood compatibility of the device for the medical treatment can be rapidly improved. The possibility of the application of MPC Polymer to the dental implant body is examined aiming to control the cellular adhesiveness to the implant body, and to be longer-term and to make the implant function in vivo surely. The kind of MPC Polymer necessary to obstruct the cellular adhesion to the titanium plate surface first of all and the density was examined.First of all, the GFP tendency was made introducing the GFP gene by using the vector of the retrovirus for leaf system stem cell stock C3H10T1/2:] with stability and the appearing cell strain was made. As a result, it turned out PMB and PMS that the cellular adhesion was equally obstructed, and PMD was low the in hibition effect of the cellular adhesion. It was assumed that the plate of the same titanium alloy as the material of the implant body that had already been sold as aproduct was used because the appearance that the cell bonded was observed by the state etc. of grinding on the surface of the titanium plate, and however, Polymer adopted PMB and did a similar experiment. As a result, the effect of the cell bonding obstruction on the titanium alloy was admitted.

阐明了MPC聚合物具有磷脂质极性基团，涂覆在材料表面控制细胞和蛋白质的粘附。结果，用于医疗的装置的生物相容性和血液相容性可以迅速提高。本研究旨在探讨MPC聚合物在牙种植体中应用的可能性，以控制细胞对种植体的粘附，使种植体在体内发挥更长期的功能。首先，使用稳定的叶系干细胞用逆转录病毒载体C3 H10 T1/2：]，导入GFP基因，进行GFP倾向性的研究，制作出现细胞株。结果表明，PMB和PMS对细胞粘附的抑制作用相当，PMD对细胞粘附的抑制作用较低。由于通过钛板表面上的研磨状态等观察到细胞结合的外观，因此假设使用了与已作为产品销售的植入体主体材料相同的钛合金板，然而，Polymer采用了PMB并进行了类似的实验。结果表明，细胞结合障碍对钛合金的影响是肯定的。