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The efficacy of biotin on the skin diseases related to dental Rats a

生物素对大鼠牙科相关皮肤病的疗效

基本信息

批准号：
18592202
负责人：
TAKAHASHI Shinichi
金额：
$ 2.24万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592202/
关键词：
pustulosis palmoplantaris biotin dental focus metal allergy IL-6 掌蹠膿疱症

项目摘要

We investigated 18 patients with pustular palmoplantaris (PPP) on the existence of osteoarthritis, periodontitis and the efficacy of biotin by scoring the severity of eruption with PPPASI (palmoplantar Pustular Psoriasis Area Severity Index). We also analyzed CD4/8 and plasma concentration of TNF-a , IL-6 and biotin before and after biotin treatment. Serum concentration of biotin was measured by competitive enzyme-linked assay.We found osteoarthritis (39%), periodontitis (56%) very frequently in these patients. However, these complications did not correlate with severity of eruptions. Elevations of plasma concentrations of IL-6 was detected in 4 of our patients, although there wasno significant. changes of CD4/8 and TNF-a . In these 4 cases three patients had severe periodontitis and one had pyelonephritisSerum concentration of biotin was about 100 times higher in the patients with administration of 9 or 12mg of biotin daily than those without biotin treatment. There was no significant difference of serum biotin concentration between patients with 9mg daily and those with 12mg daily. This result means 9mg of biotin per''day is enough for the treatment of the patients with PPP.Biotin was very effective for 14(78%)patients investigated. PPPASI of the patients was significantly lowered after biotin treatment (p<0.01). Biotin was also effective for the osteoarthritis. Serum IL-6 concentration was significantly decreased after biotin treatment (p<0.01). Furthermore, we confirmed synergic effect of dental treatment on eruptions and osteoarthritis of the patients with PPP.These results indicate IL-6 may be a useful marker for severe periodontitis in the patients with PPP. We also suggest biotin (9mg daily) together with dental treatment for periodontitis is quite effective for PPP.

采用PPPASI（palmoplantar pustular Psestulum Area Severity Index）评分法，对18例掌跖脓疱性（PPP）患者进行了骨关节炎、牙周炎及生物素治疗的疗效观察。我们还分析了生物素治疗前后的CD 4/8和TNF-α、IL-6和生物素的血浆浓度。血清生物素浓度测定采用竞争酶联法，结果发现骨关节炎（39%）、牙周炎（56%）是最常见的疾病。然而，这些并发症与皮疹的严重程度无关。4例患者血浆IL-6浓度升高，但无显著性差异。CD 4/8和TNF-α的变化。在这4例患者中，3例有严重的牙周炎，1例有肾盂肾炎。每天服用9或12 mg生物素的患者血清生物素浓度比未服用生物素的患者高约100倍。9 mg/d组与12 mg/d组血清生物素浓度无显著性差异。这一结果意味着每天9 mg生物素足以治疗PPP患者，14例（78%）患者生物素非常有效。生物素治疗后PPPASI明显降低（P<0.01）。生物素对骨关节炎也有效。治疗后血清IL-6浓度显著降低（P<0.01）。此外，我们证实了牙齿治疗对PPP患者的出疹和骨关节炎的协同作用，这些结果表明IL-6可能是PPP患者严重牙周炎的有用标志物。我们还建议，生物素（每天9毫克）与牙周炎的牙科治疗是相当有效的PPP。