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Objective measurement of patch test reactions due to dental metal compounds by measuring the erythema index and quantity of corneous moisture

通过测量红斑指数和角质水分含量来客观测量牙科金属化合物引起的斑贴试验反应

基本信息

批准号：
16592021
负责人：
TAKAHASHI Shinichi
金额：
$ 0.7万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16592021/
关键词：
dental metal allergy patch test eryhtema index quantity of corneous moisture

项目摘要

Using the mice delayed hypersensitivity to dinitrochlorobenzene model, we compared the ear swelling rate with erythema index (E.I. ; measured with MEXAMETER MX18【○!R】) and quantity of corneous moisture (Q.G.M. ; measured with CORNEOMETER CM825【○!R】). The ear swelling rate showed a highly significant positive correlation with E.I. but not with Q.C.M. Therefore, E.I was employed for the objective assessment of patch test reactions.To establish the optimal method for this assessment, we measured the effects of measurement intervals and tape application on E.I. during the patch test reactions in normal volunteers. At the site of metal compound and tape application, E.I. was significantly higher within 30 min after tape removal than after >40 min. E.I. was significantly higher on the 2nd,3rd, and 7th day post-patch test than before the patch test. We concluded that to eliminate the effects of tape application on E.I. most effectively, the standard deviation value (S.D.V) of E.I. at the test site should be preferred over E.I. at the control sites (sites of adjacent tape application and the adjacent normal skin).We measured the S.D.V. of E.I. in patients with metal allergy (n=10), in those with an irritant reaction (n=10), and in the control group (n=10) on the 2nd,3rd, and 7th day post-patch test. The S.D.V. of E.I. was significantly higher in patients with metal allergy than in the control group on all days examined. S.D.V. was higher in patients with irritant reactions than in the control group on the 2nd and 3rd day, but not on the 7th day. Only on the 7th day, patients with metal allergy had a higher S.V.D. than those with an irritant reaction. These results suggested that patch test reactions can be objectively assessed with MEXAMETER by employing consecutive measurements.

利用小鼠对二硝基氯苯迟发型过敏模型，我们将耳部肿胀率与红斑指数（E.I.；用MEXAMETER MX18【○！R】测量）和角质水分含量（Q.G.M.；用CORNEOMETER CM825【○！R】测量）进行比较。耳肿胀率与E.I.呈极显着正相关。但 Q.C.M 则不然。因此，采用 E.I 来客观评估斑贴试验反应。为了建立此评估的最佳方法，我们测量了测量间隔和胶带应用对 E.I 的影响。在正常志愿者的斑贴测试反应期间。在金属化合物和胶带应用现场，E.I.胶带去除后 30 分钟内的浓度显着高于 >40 分钟后的浓度。 E.I.斑贴试验后第2、3、7天明显高于斑贴试验前。我们的结论是，要消除胶带应用对 E.I. 的影响。最有效的是，E.I. 的标准偏差值 (S.D.V)在测试现场应该优先于 E.I.在对照部位（邻近胶带粘贴部位和邻近正常皮肤）。我们测量了 S.D.V. E.I.的金属过敏患者 (n=10)、有刺激反应的患者 (n=10) 以及对照组 (n=10) 在斑贴试验后第 2、3 和 7 天进行。 S.D.V. E.I.的在检查的所有天数中，金属过敏患者的显着高于对照组。 S.D.V.出现刺激反应的患者在第2天和第3天高于对照组，但在第7天则不高于对照组。仅在第 7 天，金属过敏患者的 S.V.D 较高。比那些有刺激反应的人。这些结果表明，可以使用 MEXAMETER 通过连续测量来客观评估斑贴试验反应。