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Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application

Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
CCN家族蛋白作为新型信号传导体的分子基础及其转化应用的综合研究
批准号:
19109008
负责人:
TAKIGAWA Masaharu
金额:
$70.72万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011

项目摘要

项目成果

TAKIGAWA Masaharu的其他基金

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中文摘要
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英文摘要
We have established a novel concept that CCN family proteins should be considered a newly classified signaling molecules that comprehensively regulate extracellular signals, and thus should be entitled "Signal Conductors." Moreover, we have accumulated basic data for application of CCN proteins toward harmonized regenerative medicine and for therapeutics of diseases with their abnormal upregulation, leading to their medical applications.
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会议论文
前十字靭帯細胞におけるCTGF/CCN2の機能と周期的伸長負荷の効果
CTGF/CCN2在前交叉韧带细胞中的功能及循环拉伸负荷的影响
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [三宅由晃, 他]
通讯作者:
CCN family 2/connective tissue growth factor(CCN2/CTGF)promotes osteoclastogenesis via interaction with dendritic cell-specific transmembrane protein(DC-STAMP)
CCN家族2/结缔组织生长因子(CCN​​2/CTGF)通过与树突状细胞特异性跨膜蛋白(DC-STAMP)相互作用促进破骨细胞生成
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Nishida T., et al.]
通讯作者: et al.
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kuroda C., et al.]
通讯作者: et al.
CCNファミリー2/結合組織成長因子(CCN2/CTGF)はDC-STAMPの遺伝子発現レベルの上昇を介して破骨細胞形成を促進する。
CCN 家族 2/结缔组织生长因子 (CCN2/CTGF) 通过增加 DC-STAMP 的基因表达水平来促进破骨细胞形成。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [西田崇, 他]
通讯作者:
192
    Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
    • 批准号:
      17K19757
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2017
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
    • 批准号:
      15H05014
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.9万
    • 财政年份:
      2015
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    A new protein transport system in cartilage: Multilayered transcytosis
    • 批准号:
      23659872
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
    • 批准号:
      15109010
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $66.48万
    • 财政年份:
      2003
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位: