Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
批准号:
19109008
负责人:
TAKIGAWA Masaharu
金额:
$70.72万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2011
中文摘要
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英文摘要
We have established a novel concept that CCN family proteins should be considered a newly classified signaling molecules that comprehensively regulate extracellular signals, and thus should be entitled "Signal Conductors." Moreover, we have accumulated basic data for application of CCN proteins toward harmonized regenerative medicine and for therapeutics of diseases with their abnormal upregulation, leading to their medical applications.
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前十字靭帯細胞におけるCTGF/CCN2の機能と周期的伸長負荷の効果
CTGF/CCN2在前交叉韧带细胞中的功能及循环拉伸负荷的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[三宅由晃, 他]
通讯作者:
他
CCN family 2/connective tissue growth factor(CCN2/CTGF)promotes osteoclastogenesis via interaction with dendritic cell-specific transmembrane protein(DC-STAMP)
CCN家族2/结缔组织生长因子(CCN2/CTGF)通过与树突状细胞特异性跨膜蛋白(DC-STAMP)相互作用促进破骨细胞生成
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nishida T., et al.]
通讯作者:
et al.
Distribution gene expression and functional role of EphA4 during ossification. The 2nd International
EphA4在骨化过程中的分布基因表达和功能作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kuroda C., et al.]
通讯作者:
et al.
CCNファミリー2/結合組織成長因子(CCN2/CTGF)はDC-STAMPの遺伝子発現レベルの上昇を介して破骨細胞形成を促進する。
CCN 家族 2/结缔组织生长因子 (CCN2/CTGF) 通过增加 DC-STAMP 的基因表达水平来促进破骨细胞形成。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[西田崇, 他]
通讯作者:
他
CCN2/CTGFによるBMP-2の軟骨細胞増殖、分化促進作用の制御
CCN2/CTGF对BMP-2软骨细胞增殖和分化促进作用的调控
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[前田あずさ, 他]
通讯作者:
他
共 192 条
Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
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批准号:17K19757
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2017
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负责人:TAKIGAWA Masaharu
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依托单位:
Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
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批准号:15H05014
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.9万
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财政年份:2015
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负责人:TAKIGAWA Masaharu
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依托单位:
A new protein transport system in cartilage: Multilayered transcytosis
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批准号:23659872
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:TAKIGAWA Masaharu
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依托单位:
The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
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批准号:15109010
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$66.48万
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财政年份:2003
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负责人:TAKIGAWA Masaharu
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依托单位:
Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals
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批准号:13307053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.71万
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财政年份:2001
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负责人:TAKIGAWA Masaharu
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依托单位:
Development of analytical method for each domain of CTGF/ecogenin and its clinical application.
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批准号:12557154
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -
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批准号:10470389
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.51万
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财政年份:1998
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负责人:TAKIGAWA Masaharu
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依托单位:
Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases
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批准号:10557165
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:1998
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负责人:TAKIGAWA Masaharu
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依托单位:
The role of hcs-24, a newly isolated hypertrophic chondrocyte-specific gene, in endochondral ossification
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批准号:08457490
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$1.22万
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财政年份:1996
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负责人:TAKIGAWA Masaharu
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依托单位:
Molecular cloning of novel osteoneurotrophins and their application as therapeutic agents for bone and cartilage diseases
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批准号:08557098
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.86万
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财政年份:1996
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负责人:TAKIGAWA Masaharu
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依托单位:
Cloning and functional analysis of novel genes related to chondrocyte differentiation using the human chondrocytic cell lines
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批准号:06454521
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.54万
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财政年份:1994
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on the mechanism of endochondral ossification using a clonal chondrocyte like cell line newly established from a human chondrosarcoma - approach using the methods of cellular and molecular biology
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批准号:03454429
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.84万
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财政年份:1991
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on mechanisms of proliferation, differentiation and calcification of chondrocytes using established clonal cell lines.
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批准号:63480411
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1988
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负责人:TAKIGAWA Masaharu
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依托单位:
Purification of cartilage-derived anti-tumor factor (CATF) and establishment of cell lines which produce CATF
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批准号:61480387
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1986
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负责人:TAKIGAWA Masaharu
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依托单位:
Bioassays for parathyrois hormone using clutures chondrocytes
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批准号:60870013
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$2.43万
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财政年份:1985
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负责人:TAKIGAWA Masaharu
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依托单位: