Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
批准号:
17K19757
负责人:
TAKIGAWA Masaharu
金额:
$4.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
财政年份:
2017
资助国家:
日本
项目状态:
已结题
起止时间:
2017-06-30 至 2020-03-31
中文摘要
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英文摘要
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Catabolic Effects of FGF-1 on Chondrocytes through MMP-13 and CCN2: Possible role in Osteoarthritis.
FGF-1 通过 MMP-13 和 CCN2 对软骨细胞的分解代谢作用:在骨关节炎中的可能作用。
DOI:
--
发表时间:
2018
期刊:
影响因子:
--
作者:
[El-Seoudi A, Abd El Kader T, Nishida T, Aoyama E, Eguchi T, Takigawa M, Kubota S]
通讯作者:
Kubota S
軟骨細胞におけるAngiotensin IIの産生調節とその作用
血管紧张素 II 产生的调节及其对软骨细胞的影响
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[西田 崇, 明石 翔, 滝川正春, 久保田聡]
通讯作者:
久保田聡
関節 成長板軟骨細胞におけるセロトニン (5-HT)によるCCN2産生の差別的制御メカニズム
关节生长板软骨细胞中血清素(5-HT)产生CCN2的差异控制机制
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[堀 綾花, 西田 崇, 高柴正悟, 久保田聡, 滝川正春]
通讯作者:
滝川正春
癌抑制遺伝子PDGFRLはCCN2、CCN3による軟骨細胞増殖と分化の制御を抑制する。
肿瘤抑制基因 PDGFRL 抑制 CCN2 和 CCN3 对软骨细胞增殖和分化的控制。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[河田かずみ, 久保田聡, 滝川正春]
通讯作者:
滝川正春
Long noncoding RNAs that regulate CCN2
调节 CCN2 的长非编码 RNA
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Kubota, S., Ishikawa, T., Mizukawa, T., Kondo, S., El-Seoudi, A., Nishida, T., Hattori, T., Kawata, K., Furumatsu, T., Takarada, T., Ono, M., Takigawa, M.]
通讯作者:
M.
共 41 条
Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
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批准号:15H05014
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.9万
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财政年份:2015
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负责人:TAKIGAWA Masaharu
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依托单位:
A new protein transport system in cartilage: Multilayered transcytosis
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批准号:23659872
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:TAKIGAWA Masaharu
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依托单位:
Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
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批准号:19109008
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$70.72万
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财政年份:2007
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负责人:TAKIGAWA Masaharu
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依托单位:
The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
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批准号:15109010
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$66.48万
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财政年份:2003
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负责人:TAKIGAWA Masaharu
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依托单位:
Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals
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批准号:13307053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.71万
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财政年份:2001
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负责人:TAKIGAWA Masaharu
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依托单位:
Development of analytical method for each domain of CTGF/ecogenin and its clinical application.
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批准号:12557154
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -
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批准号:10470389
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.51万
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财政年份:1998
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负责人:TAKIGAWA Masaharu
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依托单位:
Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases
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批准号:10557165
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:1998
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负责人:TAKIGAWA Masaharu
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依托单位:
The role of hcs-24, a newly isolated hypertrophic chondrocyte-specific gene, in endochondral ossification
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批准号:08457490
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$1.22万
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财政年份:1996
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负责人:TAKIGAWA Masaharu
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依托单位:
Molecular cloning of novel osteoneurotrophins and their application as therapeutic agents for bone and cartilage diseases
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批准号:08557098
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.86万
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财政年份:1996
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负责人:TAKIGAWA Masaharu
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依托单位:
Cloning and functional analysis of novel genes related to chondrocyte differentiation using the human chondrocytic cell lines
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批准号:06454521
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.54万
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财政年份:1994
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on the mechanism of endochondral ossification using a clonal chondrocyte like cell line newly established from a human chondrosarcoma - approach using the methods of cellular and molecular biology
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批准号:03454429
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.84万
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财政年份:1991
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on mechanisms of proliferation, differentiation and calcification of chondrocytes using established clonal cell lines.
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批准号:63480411
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1988
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负责人:TAKIGAWA Masaharu
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依托单位:
Purification of cartilage-derived anti-tumor factor (CATF) and establishment of cell lines which produce CATF
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批准号:61480387
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1986
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负责人:TAKIGAWA Masaharu
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依托单位:
Bioassays for parathyrois hormone using clutures chondrocytes
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批准号:60870013
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$2.43万
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财政年份:1985
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负责人:TAKIGAWA Masaharu
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依托单位:
海外基金