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A new protein transport system in cartilage: Multilayered transcytosis

A new protein transport system in cartilage: Multilayered transcytosis
软骨中新的蛋白质运输系统:多层转胞吞作用
批准号:
23659872
负责人:
TAKIGAWA Masaharu
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Protein transportation in cartilage has been believed to be due to diffusion because there is no blood vessel in cartilage. In the present study, we revealed that low-density lipoprotein receptor-related protein-1(LRP-1) transports connective tissue growth factor/CCN family 2 (CTGF/CCN2/CCN2)in cartilage by transcytosis, indicating that this mechanism is a new protein transport system in cartilage. We also uncovered that cartilage-specific defect of LRP-1 resulted in skeletal disorders.
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会议论文
低密度リポタンパク受容体関連タンパ1(LRP1)による軟骨細胞でのCCNファミリー2/結合組織成長因子(CCN2/CTGF)タンパク質輸送
CCN 家族 2/结缔组织生长因子 (CCN2/CTGF) 通过低密度脂蛋白受体相关蛋白 1 (LRP1) 在软骨细胞中转运蛋白
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [河田かずみ, 久保田聡, 江口傑徳, 青山絵理子, 近藤誠二, 滝川正春]
通讯作者: 滝川正春
Role of low-density lipoprotein receptor related protein 1(LRP1) in CCN2/connective tissue growth factor(CTGF) protein transport in chondrocytes.
低密度脂蛋白受体相关蛋白 1 (LRP1) 在软骨细胞 CCN2/结缔组织生长因子 (CTGF) 蛋白转运中的作用。
DOI: --
发表时间: 2012
期刊: J Cell Sci.
影响因子: --
作者: [Kawata., K., Kubota, S., (中4名), Nishida, T. and Takigawa, M.]
通讯作者: M.
DOI: 10.1002/jcp.21930
发表时间: 2010-01-01
期刊: JOURNAL OF CELLULAR PHYSIOLOGY
影响因子: 5.6
作者: [Kawata, Kazumi, Kubota, Satoshi, Takigawa, Masaharu]
通讯作者: Takigawa, Masaharu
Role of the low-densitylipoprotein receptor-related protein 1 (LRP1) in CCN2 protein transportation in chondrocytes.
低密度脂蛋白受体相关蛋白 1 (LRP1) 在软骨细胞 CCN2 蛋白运输中的作用。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kawata, K., et al.]
通讯作者: et al.
12
    Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
    • 批准号:
      17K19757
    • 项目类别:
      Grant-in-Aid for Challenging Research (Exploratory)
    • 资助金额:
      $4.16万
    • 财政年份:
      2017
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
    • 批准号:
      15H05014
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.9万
    • 财政年份:
      2015
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
    • 批准号:
      19109008
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $70.72万
    • 财政年份:
      2007
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
    • 批准号:
      15109010
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $66.48万
    • 财政年份:
      2003
    • 负责人:
      TAKIGAWA Masaharu
    • 依托单位:
    海外基金