A new protein transport system in cartilage: Multilayered transcytosis
A new protein transport system in cartilage: Multilayered transcytosis
批准号:
23659872
负责人:
TAKIGAWA Masaharu
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Protein transportation in cartilage has been believed to be due to diffusion because there is no blood vessel in cartilage. In the present study, we revealed that low-density lipoprotein receptor-related protein-1(LRP-1) transports connective tissue growth factor/CCN family 2 (CTGF/CCN2/CCN2)in cartilage by transcytosis, indicating that this mechanism is a new protein transport system in cartilage. We also uncovered that cartilage-specific defect of LRP-1 resulted in skeletal disorders.
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低密度リポタンパク受容体関連タンパ1(LRP1)による軟骨細胞でのCCNファミリー2/結合組織成長因子(CCN2/CTGF)タンパク質輸送
CCN 家族 2/结缔组织生长因子 (CCN2/CTGF) 通过低密度脂蛋白受体相关蛋白 1 (LRP1) 在软骨细胞中转运蛋白
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[河田かずみ, 久保田聡, 江口傑徳, 青山絵理子, 近藤誠二, 滝川正春]
通讯作者:
滝川正春
Role of low-density lipoprotein receptor related protein 1(LRP1) in CCN2/connective tissue growth factor(CTGF) protein transport in chondrocytes.
低密度脂蛋白受体相关蛋白 1 (LRP1) 在软骨细胞 CCN2/结缔组织生长因子 (CTGF) 蛋白转运中的作用。
DOI:
--
发表时间:
2012
期刊:
J Cell Sci.
影响因子:
--
作者:
[Kawata., K., Kubota, S., (中4名), Nishida, T. and Takigawa, M.]
通讯作者:
M.
DOI:
10.1002/jcp.21930
发表时间:
2010-01-01
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
影响因子:
5.6
作者:
[Kawata, Kazumi, Kubota, Satoshi, Takigawa, Masaharu]
通讯作者:
Takigawa, Masaharu
Role of the low-densitylipoprotein receptor-related protein 1 (LRP1) in CCN2 protein transportation in chondrocytes.
低密度脂蛋白受体相关蛋白 1 (LRP1) 在软骨细胞 CCN2 蛋白运输中的作用。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kawata, K., et al.]
通讯作者:
et al.
DOI:
10.1371/journal.pone.0059226
发表时间:
2013
期刊:
PloS one
影响因子:
3.7
作者:
[Tomita N, Hattori T, Itoh S, Aoyama E, Yao M, Yamashiro T, Takigawa M]
通讯作者:
Takigawa M
共 12 条
Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration
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批准号:17K19757
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$4.16万
-
财政年份:2017
-
负责人:TAKIGAWA Masaharu
-
依托单位:
Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research
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批准号:15H05014
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.9万
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财政年份:2015
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负责人:TAKIGAWA Masaharu
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依托单位:
Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application
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批准号:19109008
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$70.72万
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财政年份:2007
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负责人:TAKIGAWA Masaharu
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依托单位:
The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
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批准号:15109010
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$66.48万
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财政年份:2003
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负责人:TAKIGAWA Masaharu
-
依托单位:
Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals
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批准号:13307053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$23.71万
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财政年份:2001
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负责人:TAKIGAWA Masaharu
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依托单位:
Development of analytical method for each domain of CTGF/ecogenin and its clinical application.
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批准号:12557154
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.45万
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财政年份:2000
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负责人:TAKIGAWA Masaharu
-
依托单位:
Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -
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批准号:10470389
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.51万
-
财政年份:1998
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负责人:TAKIGAWA Masaharu
-
依托单位:
Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases
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批准号:10557165
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:1998
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负责人:TAKIGAWA Masaharu
-
依托单位:
The role of hcs-24, a newly isolated hypertrophic chondrocyte-specific gene, in endochondral ossification
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批准号:08457490
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$1.22万
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财政年份:1996
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负责人:TAKIGAWA Masaharu
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依托单位:
Molecular cloning of novel osteoneurotrophins and their application as therapeutic agents for bone and cartilage diseases
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批准号:08557098
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$12.86万
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财政年份:1996
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负责人:TAKIGAWA Masaharu
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依托单位:
Cloning and functional analysis of novel genes related to chondrocyte differentiation using the human chondrocytic cell lines
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批准号:06454521
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.54万
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财政年份:1994
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on the mechanism of endochondral ossification using a clonal chondrocyte like cell line newly established from a human chondrosarcoma - approach using the methods of cellular and molecular biology
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批准号:03454429
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.84万
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财政年份:1991
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负责人:TAKIGAWA Masaharu
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依托单位:
Studies on mechanisms of proliferation, differentiation and calcification of chondrocytes using established clonal cell lines.
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批准号:63480411
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1988
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负责人:TAKIGAWA Masaharu
-
依托单位:
Purification of cartilage-derived anti-tumor factor (CATF) and establishment of cell lines which produce CATF
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批准号:61480387
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1986
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负责人:TAKIGAWA Masaharu
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依托单位:
Bioassays for parathyrois hormone using clutures chondrocytes
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批准号:60870013
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项目类别:Grant-in-Aid for Developmental Scientific Research
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资助金额:$2.43万
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财政年份:1985
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负责人:TAKIGAWA Masaharu
-
依托单位:
海外基金