Clinicopathological study of risk factors for degenerative dementia : the Hisayama Study
Clinicopathological study of risk factors for degenerative dementia : the Hisayama Study
批准号:
19300125
负责人:
IWAKI Toru
金额:
$9.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We examined the association between diabetes-related factors and pathology of Alzheimer's disease in the Hisayama study. The results suggest that hyperinsulinemia and hyperglycemia caused by insulin resistance accelerate neuritic plaque formation in combination with the effects of APOE ε4. There were no relationships between diabetes-related factors and neurofibrillary tangles.
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DOI:
10.1136/jnnp.2008.155481
发表时间:
2009-04-01
期刊:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
影响因子:
11
作者:
[Matsui, Y., Tanizaki, Y., Kiyohara, Y.]
通讯作者:
Kiyohara, Y.
ペントサンポリ硫酸治療症例におけるプリオン蛋白重合度変化の解析
多硫酸戊聚糖治疗后朊病毒蛋白聚合度变化分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H, Shimohama S, Kato S, Hirano A, Tomimoto H, Ito H, Takahashi R, 本田裕之]
通讯作者:
本田裕之
Insulin resistance is associated with the pathology of Alzheimer's disease : the Hisayama Study.
胰岛素抵抗与阿尔茨海默病的病理有关:久山研究。
DOI:
--
发表时间:
2010
期刊:
Neurology (in press)
影响因子:
--
作者:
[Matsuzaki T, et al.]
通讯作者:
et al.
Insulin resistance is associated with the pathology of Alzheimer' s disease: the Hisayama Study.
胰岛素抵抗与阿尔茨海默病的病理有关:久山研究。
DOI:
--
发表时间:
期刊:
Neurology (in press)
影响因子:
--
作者:
[Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T]
通讯作者:
Iwaki T
プリオン病モデルマウスおける重合プリオン蛋白形成の経時的解析
朊病毒病模型小鼠聚合朊病毒蛋白形成的时程分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Kinjo S, Hirato, J, Nakazato Y, 佐々木健介]
通讯作者:
佐々木健介
共 19 条
Molecular analysis of prion protein oligomers by single molecule fluorescence imaging
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批准号:24650186
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
-
财政年份:2012
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负责人:IWAKI Toru
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依托单位:
Association of life-style related risk factors with the pathology of dementia
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批准号:22300116
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
-
财政年份:2010
-
负责人:IWAKI Toru
-
依托单位:
Clinicopathological study of dementia : the Hisayama study
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批准号:16300112
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.06万
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财政年份:2004
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负责人:IWAKI Toru
-
依托单位:
Molecular changes at the posterior horn of spinal cord resulting from spinal root avulsion
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批准号:12680733
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2000
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负责人:IWAKI Toru
-
依托单位:
Molecular analysis of tumorigenesis human ependymoma.
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批准号:10670163
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1998
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负责人:IWAKI Toru
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依托单位:
Function of alphaB-crystallin in brain development and neurodegeneration
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批准号:06454694
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.58万
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财政年份:1994
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负责人:IWAKI Toru
-
依托单位:
Accumulation of alphaB-crystallin in glioma cells and the relation to oncogene expression.
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批准号:04670213
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1992
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负责人:IWAKI Toru
-
依托单位:
Molecular analysis of alphaB-crystallin in central nervous system and in pathologic conditions.
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批准号:02670154
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项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.47万
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财政年份:1990
-
负责人:IWAKI Toru
-
依托单位:
海外基金