The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol
The study on functional food using oxidative stress marker, hydroxyoctadecadienoic acid and 7-hydroxycholesterol
批准号:
19300256
负责人:
YOSHIDA Yasukazu
金额:
$9.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
Lipid peroxidation products have received a great deal of attention for the partical application to clinical use as bio-markers. To assess the antioxidative role of functional foods and antioxidants, vitamin E and BO-653, in a mouse model and culture cell using lipid peroxidation and protein oxidation products. In the present study, we proposed that lipid peroxidation (tHODE and tOHCh) and protein oxidation are indeed good markers for the detection of progression of oxidative stress and effect of functional foods.
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Gamma-tocopheryl quinine, not alpha-tocopheryl quinine, induces adaptive response through up-regulation of cellular glutathione and cysteine anailability via activation ATF4.
γ-生育酚奎宁(而非 α-生育酚奎宁)通过激活 ATF4 上调细胞谷胱甘肽和半胱氨酸可用性来诱导适应性反应。
DOI:
--
发表时间:
2008
期刊:
Free Radical Resarch vol.42
影响因子:
--
作者:
[小川陽子, 斎藤芳郎, 西尾敬子, 吉田康一, 芦田均, 二木鋭雄]
通讯作者:
二木鋭雄
Antioxidant effects of 2, 3-dihydro-5-hydroxy-4, 6-di-tert-butyl-2, 2-dipentylbenzofur an and a-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.
通过羟基十八碳二烯酸和 7-羟基胆固醇评估 2, 3-二氢-5-羟基-4, 6-二叔丁基-2, 2-二戊基苯并呋喃和 α-生育酚对高脂血症小鼠的抗氧化作用。
DOI:
--
发表时间:
2007
期刊:
Biochemical Pharmacology vol.74
影响因子:
--
作者:
[吉田康一, 早川三恵子, 伊藤奈々子, 羽渕洋子, 井上ルリ子, Zhi-Hua Chen, Jiaofei Cao, Cynshi Osamu, Jishage Kou-Ichi, 二木鋭雄]
通讯作者:
二木鋭雄
Acceleration of lipid peroxidation in a-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical Initiator
α-生育酚转移蛋白敲除小鼠饮用含有自由基引发剂的饮用水后脂质过氧化加速
DOI:
--
发表时间:
2008
期刊:
Journal of Oleo Science 57
影响因子:
--
作者:
[Yoshida Y., et al]
通讯作者:
et al
酸化DJ-1とパーキンソン病(1)抗体作成とELISA開発
氧化DJ-1与帕金森病(1)抗体生产和ELISA开发
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[斎藤芳郎, 小川陽子, 吉田康一, 二木鋭雄]
通讯作者:
二木鋭雄
Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidativestress induced by selenium deficiency and free radicals
在缺硒和自由基引起的氧化应激下,培养细胞中的胆固醇比亚油酸盐更容易被氧化
DOI:
--
发表时间:
2007
期刊:
FEBS Lett 581
影响因子:
--
作者:
[Saito Y, Yoshida Y, and Niki E]
通讯作者:
and Niki E
共 13 条
Molecular basis of oxidative stress-induced circadian disruption and sleep disorder
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批准号:23651031
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2011
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负责人:YOSHIDA Yasukazu
-
依托单位:
The study on the biological significance of novel biomarkers for the early detection of life-related diseases
-
批准号:22300242
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.48万
-
财政年份:2010
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负责人:YOSHIDA Yasukazu
-
依托单位:
海外基金