Chemical Biology of Stem cell differentiation

我们计划寻找对研究干细胞向血管系统分化的控制机制有用的小分子。我们研究了海洋天然抗血管生成化合物azumamides在体外小鼠iPS细胞血管重组模型中的应用，并证实了其有效作用。因此，该模型以及使用小鼠胚胎干细胞的模型被证明对干细胞分化系统的研究是有用的。接下来，我们评估了格拉定类似物的抗血管生成作用，其中除了已知的MMP外，我们可以确定格拉定的未知靶点。

We were planning to find small molecules useful for the study of the controlling mechanism of stem cell differentiation to vascular systems. We have studied application of marine natural anti-angiogenic compounds, azumamides, to the in vitro vascular re-organizing model using mouse iPS cells, in which we confirmed their potent effects. Therefore, this model, as well as that using mouse ES cells, was shown to be useful for the study of stem cell differentiation systems. Next, we have evaluated anti-angiogenic effects of analogues of geladine, in which we could identified unknown targets for ageladines besides the known MMP.