Theoretical modeling and experimental verification of thermal dispersion for its applications in porous media and exploration of bio-transfer mechanism

热分散在多孔介质中的应用的理论建模和实验验证以及生物传递机制的探索

• 批准号: 19360099
• 负责人: NAKAYAMA Akira
• 金额: $ 11.73万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19360099/
• 关键词: 生体組織; 多孔質; 熱分散; 多孔質体; 機械的分散; 濃度計測; 流れの可視化; 数値シミュレーション; 多孔質対

今まで,様々な形で提案されてきた生体組織の熱輸送の式について,多孔質体理論に基づき検討した.局所体積平均理論を用いることで,最小の仮定の下に,三次元一般生体熱移動の式が導かれることを示した.今回初めて対向する動脈と静脈の灌流の効果に加え,機械的分散の効果を加味することに成功した.この三次元一般生体熱移動の式を用いて,肺癌の冷凍壊死療法における凍結過程のシミュレーションを実施した.本研究で確立した機械的分散のモデルおよび三次元一般生体熱移動の式が,工業的応用や生体輸送機構を考える上で極めて有効であることが分かった.

In this paper, we propose a new model for heat transport in biological tissues, which is based on porous theory. The volume average theory of local bodies is applied to the equation of three-dimensional general heat transfer of living bodies. At the beginning of this period, the effect of arterial venous perfusion was increased, and the effect of mechanical dispersion was successfully modified. This three-dimensional general heat transfer formula is used to implement the freezing process in cryosurgery for lung cancer. This study establishes a three-dimensional formula for heat transfer in general and industrial applications.

项目成果

Why do we have a bronchial tree with 23 levels of bifurcation?

为什么我们的支气管树有23级分叉？

• 发表时间: 2009
• 期刊: HEAT AND MASS TRANSFER Volume:45Issue:3
• 作者: A. Nakayama;F. Kuwahara;Y. Sano
• 通讯作者: Y. Sano

The Limiting Radius for Freezing a Tumor During Percutaneous Cryoablation

• DOI: 10.1115/1.2969759
• 发表时间: 2008-11
• 期刊: Journal of Heat Transfer-transactions of The Asme
• 作者: A. Nakayama;Yusuke Kuwahara;Kansei Iwata;M. Kawamura

A study on interstitial heat transfer in consolidated and unconsolidated porous media

• DOI: 10.1007/s00231-009-0513-x
• 发表时间: 2009-07
• 期刊: Heat and Mass Transfer
• 影响因子: 2.2
• 作者: A. Nakayama;K. Ando;Chen Yang;Y. Sano;F. Kuwahara;Jianjun Liu