Development of anti-obese dietary peptides which functions via gut hormone secretion

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From various dietary peptides, we found that country bean peptide and beer yeast peptide have potent activity to stimulate a satiating gut hormone CCK in enteroeondcrine cell line. Oral preload of beer yeast peptide reduced following food consumption in rats. We also found that a hydrolysate prepared from corn protein Zein stimulates another gut hormone GLP-1. Ileal administration of Zein hydrolysate strongly induced GLP-1 secretion and subsequent insulin secretion in awake rats, which results in the improvement of glucose tolerance. These findings have revealed that dietary peptides are promising factor for prevention of overeating and hyperglycemia via stimulating gut hormone secretions.