Enhancement of colonic calcium absorption in rats fed dietary fiber

膳食纤维喂养大鼠结肠钙吸收的增强

• 批准号: 06660141
• 负责人: HARA Hiroshi
• 金额: $ 1.22万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06660141/
• 关键词: CALCIUM; LARGE INTESTINE; DIETARY FIBER; ABSORPTION; RENAL FAILURE; RATS; ビタミンD

1) Intensity of cecal calcium absorption was increased after feeding of eater-soluble and high fermentable dietary fiber, which was evaluated by arterio-cecal venous difference in calcium concentration.2) We estimate capacity of calcium absorption in the large intestine by infusion of calcium solution into the cecum. The large intestinal absorption was more than 80% of calcium administered into the cecum, and that is enhanced by dietary fiber feeding.3) Absorption of insoluble calcium source from the small intestine was lower than soluble calcium source, but the lower absorption was compensated with the large intestinal absorption.4) Calcium absorption was impaired by renal failure, but the lowered calcium absorption was increased by feeding of a soluble fiber, guar gum hydrolysate. The enhancement of calcium absorption by dietary fiber was completely ablished by cecectomy. The result demonstrates that the enhancement of calcium absorption in renal failure rats fed guar gum hydrolysate is responsible for the large intestinal absorption.

1)通过盲肠动-静脉钙浓度差来评价盲肠钙吸收强度的变化。2）通过向盲肠内注入钙溶液来评价大肠钙吸收能力。小肠对不溶性钙源的吸收低于可溶性钙源，但小肠对可溶性钙源的吸收可以弥补小肠对可溶性钙源的吸收; 4）肾功能衰竭会影响钙的吸收，但通过喂入可溶性纤维瓜尔胶水解产物增加了降低的钙吸收。盲肠切除术完全证实了膳食纤维对钙吸收的促进作用。结果表明，瓜尔胶水解物对肾功能衰竭大鼠钙吸收的促进作用是其在大肠的吸收机制之一。

项目成果

H.Hara,Y.Saito,A,Idei S.Kiriyama: "Food Hydro colloids" Plenum Publishing Co., 510 (1994)

H.Hara，Y.Saito，A，Idei S.Kiriyama：“食品水胶体”Plenum Publishing Co.，510（1994）

A.Ohta,S.Baba,M.Ohtsuki,A.Taguchi,T.Adachi,H.Hara: "Prevention of coprophagy modified magnesium absorption in rats fed fructooligosaccharides." Br.J.Nutr.(in press).

A.Ohta、S.Baba、M.Ohtsuki、A.Taguchi、T.Adachi、H.Hara：“预防食粪改变喂食低聚果糖的大鼠的镁吸收。”

A. Ohta, S. Baba, M. Ohtsuki, A. Taguchi, T. Adachi, H. Hara: "Prevention of coprophagy modified magnesium absorption in rats fed fructooligosaccharides." Br. J. Nutr.(in press).

A. Ohta、S. Baba、M. Ohtsuki、A. Taguchi、T. Adachi、H. Hara：“预防食粪改变喂食低聚果糖的大鼠的镁吸收。”

H.Hara,Y.Saito,M.Nagata,M.Tsuji,K.Yamamoto: "Artificial fiber complexes composed of cellulose and guar gum or psyllium may be better sources of soluble fiber than comparable fiber mixtures in rats." J.Nutr.124. 1238-1247 (1994)

H.Hara、Y.Saito、M.Nagata、M.Tsuji、K.Yamamoto：“在大鼠中，由纤维素和瓜尔豆胶或车前子组成的人造纤维复合物可能是比同类纤维混合物更好的可溶性纤维来源。”

H. Hara, Y. Saito, A. Idei, S. Kiriyama: "Food Hydrocolloids" Plenum Publishing Co., 510 (1994)

H. Hara、Y. Saito、A. Idei、S. Kiriyama：“食品亲水胶体”Plenum Publishing Co.，510（1994）