Molecular physiology toward making non-regressing corpus luteum in the cow

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Establishment of pregnancy is a basic phenomenon for the conserved strategy of species. In mammals, progesterone released from the corpus luteum has an essential key to establish pregnancy. The aim of the present study is to elucidate molecular mechanisms of development and regression of the bovine corpus luteum, and to give the new vision of the developing technologies for improvement of conception rate in the cow. From the results of the present study, we clearly showed that PGF_<2α>, a luteolytic factor, starts the luteolytic cascade within 5 minutes after intramascular injection in the cow, and PGF_<2α> stimulates luteolytic mediators within the corpus luteum. Addktionally, we showed the delay of luteolysis due to functional suppression of luteolytic mediators such as NOS, endothelin or angiotensin II.