Study on the transport of proteins in alveolar type I/II epithelial cells for the development of new pulmonary DDS systems

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The uptake of albumin by primary cultured alveolar type II cells was higher than that by type I cells, and was clathrin-mediated endocytosis. Insulin uptake rate was similar between type II and type I cells, and clathrin-mediated system would not be so important in both cells. Insulin was taken up by endocytosis in RLE-6TN cells, and the uptake was markedly stimulated by cationic polyamino acids. The stimulation of insulin absorption from the lung by polyamino acids was also observed in vivo. These results provide important information for the development of new pulmonary drug delivery systems.