Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects
Search for traditional medicines in Thailand and scientific evaluation of their pharmacological effects
批准号:
19406004
负责人:
TAKANO Mikihisa
金额:
$6.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In Thailand, many traditional medicines are used for therapy and health promotion. Based on the discussion with colleagues in Thailand, some Thai plant extracts and purified compounds were generously provided. The pharmacological effects of these extracts and compounds were examined ; especially the effects on anticancer drug-resistant tumor cells. It was found that certain extracts potentiated the effect of anticancer effect of the drug, while another extract has potential anticancer effect by itself. These results would provide important information for the development of novel anticancer chemotherapies.
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タイ国産植物成分の多剤耐性克服作用および抗がん作用に関する検討
泰国国产植物成分克服多药耐药性及抗癌作用的研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R., Ryoko Yumoto, 川見昌史, 川見 昌史]
通讯作者:
川見 昌史
タイ国産植物成分のP-glycoprotein阻害作用, paclitaxel耐性克服作用および抗がん作用に関する検討
泰国国产植物成分的P-糖蛋白抑制作用、紫杉醇耐药性克服作用及抗癌作用研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R., Ryoko Yumoto, 川見昌史]
通讯作者:
川見昌史
Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in human hepatoma cell line HepG2.
人肝癌细胞系 HepG2 中紫杉醇流出和流入转运蛋白的表达改变导致紫杉醇抗性。
DOI:
--
发表时间:
2009
期刊:
Drug Metab. Pharmacokinet. 24(5)
影响因子:
--
作者:
[Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R.]
通讯作者:
R.
Effect of Thai plant extracts on P-glycoprotein function and cell viability in HepG2 and paclitaxel-resistant HepG2 cells2
泰国植物提取物对 HepG2 和紫杉醇耐药 HepG2 细胞 P-糖蛋白功能和细胞活力的影响2
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R., Ryoko Yumoto]
通讯作者:
Ryoko Yumoto
抗癌剤処理によるcell viability の変動とABCトランスポーターの発現・機能との相関解析:ヒト肺癌由来A549細胞を用いて
抗癌药物治疗引起的细胞活力变化与ABC转运蛋白表达/功能的相关性分析:使用人肺癌来源的A549细胞
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Takano, M., Otani Y., Tanda, M., Kawami, M., Nagai, J., Yumoto, R., Ryoko Yumoto, 川見昌史, 川見 昌史, 福井 杏子]
通讯作者:
福井 杏子
Analysis of low temperature tolerance of membrane transporters and development of pan-transporter inhibitors
-
批准号:23659081
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2011
-
负责人:TAKANO Mikihisa
-
依托单位:
Research on the anticancer effects and multidrug-resistance modulating effects of Thai plants
-
批准号:23406005
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.65万
-
财政年份:2011
-
负责人:TAKANO Mikihisa
-
依托单位:
Establishment of a new alveolar epithelial cell model by gene transfection and its application to the study on drug transport and toxicity in the lungs
-
批准号:22390031
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.32万
-
财政年份:2010
-
负责人:TAKANO Mikihisa
-
依托单位:
Study on the transport of proteins in alveolar type I/II epithelial cells for the development of new pulmonary DDS systems
-
批准号:19390043
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.15万
-
财政年份:2007
-
负责人:TAKANO Mikihisa
-
依托单位:
Development of protein drug delivery system from the lung based on ligand recognition mechanisms of the receptors
-
批准号:17590125
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2005
-
负责人:TAKANO Mikihisa
-
依托单位:
Studies on the mechanisms underlying renal tubular deficiency due to the lack of the expression and function of CLCN5, a gene responsible for Dent's disease
-
批准号:13672287
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
-
负责人:TAKANO Mikihisa
-
依托单位:
Search for the new, endogenous compound with multidrug resistance modulating activity and its application to cancer chemotherapy
-
批准号:11672169
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:1999
-
负责人:TAKANO Mikihisa
-
依托单位:
海外基金