Analysis of pathological significance of a cell adhesion molecule TSLC1 in male infertility and in ulcerative colitis
Analysis of pathological significance of a cell adhesion molecule TSLC1 in male infertility and in ulcerative colitis
批准号:
19390091
负责人:
MURAKAMI Yoshinori
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
細胞接着分子TSLC1 の男性不妊症、潰瘍性大腸炎における病理学的意義を検討した。Tslc1遺伝子欠損マウスが精子形成障害を示す知見に基づき、130 例のヒト男性不妊症例を解析し、TSLC1 タンパク質発現欠如を示す6 例を見出したが遺伝子変異は認めなかった。一方、TSLC1遺伝子の転写制御機構を解明し、精巣での新規結合タンパク質を同定した。さらにTSLC1 タンパク質の発現が潰瘍性大腸炎の病勢に相関することを見出した。
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Involvement of the SgIGSF/Necl-2 adhesion molecule in degradation of mesenteric mast cells.
SgIGSF/Necl-2 粘附分子参与肠系膜肥大细胞的降解。
DOI:
--
发表时间:
2007
期刊:
J Neuro Immunol. 184
影响因子:
--
作者:
[Ito A, Hagiyama M, Oonuma J, Murakami Y, Yokozaki H, Takaki M]
通讯作者:
Takaki M
ヒト家族性腫瘍のモデルとしてのTslc1/Cadm1 遺伝子欠損マウスの解析
Tslc1/Cadm1 基因缺陷小鼠作为人类家族性肿瘤模型的分析
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[山田大介, 永田政義, 尾鼻孝滋, 増田万里, 市原博美, 増田智子, 吉田緑, 堤雅弘, 北村唯一, 村上善則]
通讯作者:
村上善則
Male gamete empowerment
雄性配子赋权
DOI:
--
发表时间:
2008
期刊:
Ann N Y Acad Sci 1127
影响因子:
--
作者:
[Takeuchi T, Neri QV, Palermo GD]
通讯作者:
Palermo GD
DOI:
10.1095/biolreprod.106.058974
发表时间:
2007-06-01
期刊:
BIOLOGY OF REPRODUCTION
影响因子:
3.6
作者:
[Wakayama, Tomohiko, Sai, Yoshimichi, Iseki, Shoichi]
通讯作者:
Iseki, Shoichi
DOI:
10.2353/ajpath.2009.080743
发表时间:
2009-06-01
期刊:
AMERICAN JOURNAL OF PATHOLOGY
影响因子:
6
作者:
[Hagiyama, Man, Ichiyanagi, Naoki, Ito, Akihiko]
通讯作者:
Ito, Akihiko
共 11 条
Platform of Supporting Cohort Study and Biospecimen Analysis
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批准号:16H06277
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项目类别:Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
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资助金额:$1456.67万
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财政年份:2016
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负责人:MURAKAMI Yoshinori
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依托单位:
Analysis of somatic alteration of copy number variation in cancer as a new instability of cancer
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依托单位:
Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis
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批准号:25290051
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.82万
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财政年份:2013
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负责人:MURAKAMI Yoshinori
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依托单位:
Usage of teaching materials and to develop teaching materials in the field of special needs education
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批准号:23653310
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.91万
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财政年份:2011
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负责人:MURAKAMI Yoshinori
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依托单位:
Control of the shell structure for the core-shell metal nano-particles using the supercritical CO2 fluid.
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批准号:23560924
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:MURAKAMI Yoshinori
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依托单位:
Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
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批准号:22300336
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.9万
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财政年份:2010
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负责人:MURAKAMI Yoshinori
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依托单位:
Anisotropic modification of the particle surface using the shock-induced sudden heating technique.
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批准号:20560711
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2008
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负责人:MURAKAMI Yoshinori
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依托单位:
Study on development of teaching materials(toys)for severe motor disabilities.-from the viewpoints of education for special needs education-
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批准号:18530743
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.63万
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财政年份:2006
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负责人:MURAKAMI Yoshinori
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依托单位:
Molecular understanding and diagnosis of human cancer through the structural, functional and expression analysis of cancer related genes.
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批准号:17015048
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$38.34万
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财政年份:2005
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负责人:MURAKAMI Yoshinori
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依托单位:
Analysis of cell adhesion and polarity formation by a novel tumor suppressor protein TSLC1 and its related molecules
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批准号:15590262
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2003
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负责人:MURAKAMI Yoshinori
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依托单位:
New Observation Method Effective in Estimating Behavioral changes in handicapped children with epilepsy.
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批准号:07610106
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.34万
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财政年份:1995
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负责人:MURAKAMI Yoshinori
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依托单位:
海外基金