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Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer

Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
细胞粘附分子的生理学和病理学分析,用于开发人类癌症的诊断标记物
批准号:
22300336
负责人:
MURAKAMI Yoshinori
金额:
$9.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Physiological and pathological roles of cell adhesion molecules in cancer development and progression were analyzed to establish novel molecular markers of human cancer. We found that a splicing variant of a cell adhesion molecule CADM1 was expressed exclusively in small cell lung cancer (SCLC), providing a candidate diagnostic marker of SCLC. We also found that CADM1 could cross-talk with the MET signaling and may play a role in acquired resistance of lung adenocarcinoma against EGFR-TKItreatment.
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Dual roles of a cell adhesion molecule, CADM1, in human lung oncogenesis based on the molecular pathological analyses.
基于分子病理学分析的细胞粘附分子 CADM1 在人肺肿瘤发生中的双重作用。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yoshinori Murakami, Mika Sakurai, Takeshi Ito, Hideki Kuwano, Daisuke Matsubara, Akiteru Goto.]
通讯作者: Akiteru Goto.
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [2.Yoshinori Murakami, Masanao Miwa, Hideo Tanaka, Masakazu Yamamoto and Puangrat Yongvanit.]
通讯作者: Masakazu Yamamoto and Puangrat Yongvanit.
東京大学医科学研究所人癌病因遺伝子分野
东京大学医学科学研究所人类癌症致病基因研究室
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1093/intimm/dxr089
发表时间: 2012-01-01
期刊: INTERNATIONAL IMMUNOLOGY
影响因子: 4.4
作者: [Abe, Jun, Ueha, Satoshi, Matsushima, Kouji]
通讯作者: Matsushima, Kouji
30
    Platform of Supporting Cohort Study and Biospecimen Analysis
    • 批准号:
      16H06277
    • 项目类别:
      Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
    • 资助金额:
      $1456.67万
    • 财政年份:
      2016
    • 负责人:
      MURAKAMI Yoshinori
    • 依托单位:
    Analysis of somatic alteration of copy number variation in cancer as a new instability of cancer
    • 批准号:
      26640121
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.0万
    • 财政年份:
      2014
    • 负责人:
      MURAKAMI Yoshinori
    • 依托单位:
    Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis
    • 批准号:
      25290051
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.82万
    • 财政年份:
      2013
    • 负责人:
      MURAKAMI Yoshinori
    • 依托单位:
    Usage of teaching materials and to develop teaching materials in the field of special needs education
    • 批准号:
      23653310
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.91万
    • 财政年份:
      2011
    • 负责人:
      MURAKAMI Yoshinori
    • 依托单位:
    海外基金