Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer
批准号:
22300336
负责人:
MURAKAMI Yoshinori
金额:
$9.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Physiological and pathological roles of cell adhesion molecules in cancer development and progression were analyzed to establish novel molecular markers of human cancer. We found that a splicing variant of a cell adhesion molecule CADM1 was expressed exclusively in small cell lung cancer (SCLC), providing a candidate diagnostic marker of SCLC. We also found that CADM1 could cross-talk with the MET signaling and may play a role in acquired resistance of lung adenocarcinoma against EGFR-TKItreatment.
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Dual roles of a cell adhesion molecule, CADM1, in human lung oncogenesis based on the molecular pathological analyses.
基于分子病理学分析的细胞粘附分子 CADM1 在人肺肿瘤发生中的双重作用。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yoshinori Murakami, Mika Sakurai, Takeshi Ito, Hideki Kuwano, Daisuke Matsubara, Akiteru Goto.]
通讯作者:
Akiteru Goto.
Towards the control of cholangiocarcinoma by international collaboration between Thailand and Japan.
通过泰国和日本之间的国际合作控制胆管癌。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[2.Yoshinori Murakami, Masanao Miwa, Hideo Tanaka, Masakazu Yamamoto and Puangrat Yongvanit.]
通讯作者:
Masakazu Yamamoto and Puangrat Yongvanit.
東京大学医科学研究所人癌病因遺伝子分野
东京大学医学科学研究所人类癌症致病基因研究室
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1093/intimm/dxr089
发表时间:
2012-01-01
期刊:
INTERNATIONAL IMMUNOLOGY
影响因子:
4.4
作者:
[Abe, Jun, Ueha, Satoshi, Matsushima, Kouji]
通讯作者:
Matsushima, Kouji
DOI:
10.1111/j.1440-1827.2011.02654.x
发表时间:
2011
期刊:
Pathology Int
影响因子:
--
作者:
[Morita S, Goto A, Sakatani T, Ota S, Murakawa T, Nakajima J, Maeda E, Fukayama M.]
通讯作者:
Fukayama M.
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批准号:16H06277
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New Observation Method Effective in Estimating Behavioral changes in handicapped children with epilepsy.
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