Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injury

间质性肺疾病和药物性肺损伤患者临床特征和基因组分析的比较研究

• 批准号: 19390224
• 负责人: KOHNO Nobuoki
• 金额: $ 12.06万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390224/
• 关键词: 呼吸器病学; 間質性肺炎; バイオマーカー; 薬剤性肺障害; 人種差; 医療・福祉; ゲノム; 糖鎖; マイクロアレイ

We elucidate a racial difference of the interstitial lung disease (ILD) by international collaborative investigation with Germany. The serum levels of KL-6 in European healthy volunteers were significantly higher than Japanese. On the other hands, serum levels of KL-6 in European ILD patients were not significantly higher than Japanese. Serum levels of KL-6 in European patients with idiopathic interstitial pneumonia (IIP) were significantly higher than European controls, and were correlated with inversely with some pulmonary function tests and BALF findings. Microarray analysis revealed that gene expression patterns clearly distinguished IIP from chronic hypersensitivity pneumonia.

我们通过与德国的国际合作研究阐明了间质性肺病（ILD）的种族差异。欧洲健康志愿者血清KL-6水平显著高于日本人。另一方面，欧洲ILD患者的血清KL-6水平并不显著高于日本患者。欧洲特发性间质性肺炎（IIP）患者的血清KL-6水平显著高于欧洲对照组，并与某些肺功能检查和BALF结果呈负相关。微阵列分析显示，基因表达模式明确区分IIP慢性过敏性肺炎。

项目成果

Genetic ablation of Bach 1 gene reduces hyperoxic lung injury in mice : role of IL-6 article type

Bach 1 基因的基因消融可减少小鼠高氧性肺损伤：IL-6 的作用 Article Type

• 发表时间: 2009
• 期刊: Free Radical Biology & Medicine 46
• 作者: Wang Z;Iwasaki Y;Zhao LF;Nishiyama M;Taguchi T;Tsugita M;Kambayashi M;Hashimoto K;Terada Y;Tanimoto T
• 通讯作者: Tanimoto T

KL-6の発見から臨床応用まで

从KL-6的发现到临床应用

• 发表时间: 2008
• 作者: 香川亨;寺田典生;河野修興
• 通讯作者: 河野修興

Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis.

• DOI: 10.1016/j.bbrc.2006.12.128
• 发表时间: 2007-02
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Hiroyasu Shoda;A. Yokoyama;Ryouhei Nishino;Taku Nakashima;N. Ishikawa;Y. Haruta;N. Hattori;T. Naka;N. Kohno

Targeted serum glycoproteomics for the discovery of lung cancer‐associated glycosylation disorders using lectin‐coupled ProteinChip arrays

• DOI: 10.1002/pmic.200800374
• 发表时间: 2009-04
• 期刊: PROTEOMICS
• 影响因子: 3.4
• 作者: K. Ueda;Y. Fukase;T. Katagiri;N. Ishikawa;S. Irie;Takashi Sato;H. Ito;H. Nakayama;Y. Miyagi;E. Tsuchiya;N. Kohno;M. Shiwa;Yusuke Nakamura;Y. Daigo

Krebs von den Lungen-6(KL-6) is a Serologic and Prognostic Biomarker and a Possible Therapeutic Target for IPF (International Symposium)

Krebs von den Lungen-6 (KL-6) 是一种血清学和预后生物标志物，也是 IPF 的可能治疗靶点（国际研讨会）

• 发表时间: 2009
• 作者: Murakami T;Moriwaki Y;Kawarabayashi T;Nagai M;Ohta Y;Deguchi K;Kurata T;Takehisa Y;Matsubara E;Ikeda M;Harigaya Y;Shoji M;Takahashi R;Abe K;久保裕司;Hirooka Y.;河野修興
• 通讯作者: 河野修興