Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injury

我们通过与德国的国际合作研究阐明了间质性肺疾病（ILD）的种族差异。欧洲健康志愿者血清KL-6水平显著高于日本人。另一方面，欧洲ILD患者血清KL-6水平不显著高于日本。欧洲特发性间质性肺炎（IIP）患者血清KL-6水平显著高于欧洲对照组，且与某些肺功能检查和BALF结果呈负相关。微阵列分析显示基因表达模式明显区分IIP和慢性超敏性肺炎。

We elucidate a racial difference of the interstitial lung disease (ILD) by international collaborative investigation with Germany. The serum levels of KL-6 in European healthy volunteers were significantly higher than Japanese. On the other hands, serum levels of KL-6 in European ILD patients were not significantly higher than Japanese. Serum levels of KL-6 in European patients with idiopathic interstitial pneumonia (IIP) were significantly higher than European controls, and were correlated with inversely with some pulmonary function tests and BALF findings. Microarray analysis revealed that gene expression patterns clearly distinguished IIP from chronic hypersensitivity pneumonia.