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Anti KL-6 antibody enhances the effects of molecular targeted drug

Anti KL-6 antibody enhances the effects of molecular targeted drug
抗KL-6抗体增强分子靶向药物疗效
批准号：
23659433
负责人：
KOHNO Nobuoki
金额：
$2.25万
依托单位：
Hiroshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659433/
关键词：
KL-6分子標的治療薬肺癌

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英文摘要
The aim of the present study was to investigate the additive effect of anti-KL-6 antibody on the therapeutic antibody-induced ADCC (Antibody-Dependent Cellular-Cytotoxicity) activity. The expression of HER2 and KL-6 were measured using FACS analysis in 4 cancer cell lines (SK-BR-3, ZR75-1, PC3, YMB-S), and both HER2 and KL-6 were highly expressed in YMB-S cells. Accordingly, the effects of anti KL-6 antibody on the ADCC activity of PBMCs evoked by Trastuzumab were examined using Cr-51 release assay. Enhanced cytotoxicity was observed in an effector-to-target ratio manner when YMB-S cells were treated with anti-KL-6 antibody. These findings indicate that anti KL-6 antibody can enhance the therapeutic antibody-induced ADCC activity mediated by mononuclear cells.
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Comparison of serum KL-6 versus bronchoalveolar lavage　neutrophilia for the diagnosis of bronchiolitis obliterans in lung　transplantation.
血清 KL-6 与支气管肺泡灌洗中性粒细胞增多症诊断肺移植闭塞性细支气管炎的比较。
DOI： 10.1016/j.healun.2011.07.010
发表时间： 2011
期刊： J Heart Lung Transplant
影响因子： --
作者： [Ohshimo S, Bonella F, Sommerwerck U, Teschler H, Kamler M, Jakob HG, Kohno N, Guzman J, Costabel U.]
通讯作者： Costabel U.
Serum KL-6 is a useful diagnostic and prognostic biomarker in idiopathic interstitial pneumonia in German patients.
血清 KL-6 是德国患者特发性间质性肺炎的有用诊断和预后生物标志物。
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Horimasu Y, Ohshimo S, Ishikawa N, Tanaka S, Yoshioka K, Bonella F, Hattori N, Kohno N, Guzman J, Costabel U.]
通讯作者： Costabel U.
Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms.
DOI： 10.1186/1471-2350-15-4
发表时间： 2014-01-08
期刊： BMC medical genetics
影响因子： --
作者： [Horimasu Y, Hattori N, Ishikawa N, Tanaka S, Bonella F, Ohshimo S, Guzman J, Costabel U, Kohno N]
通讯作者： Kohno N
Discovery and clinical application of KL-6, a circulating biomarker for interstitial lung diseases
间质性肺疾病循环生物标志物KL-6的发现及临床应用
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Miyake K, Tani K, Kakiuchi S, Suzuka C, Toyoda Y, Kishi J, Tezuka T, Yuasa S, Hanibuchi M, Aono Y, Nishioka Y, Sone S, Kohno N]
通讯作者： Kohno N
共 28 条
    Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injury
    • 批准号：
      19390224
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $12.06万
    • 财政年份：
      2007
    • 负责人：
      KOHNO Nobuoki
    • 依托单位：
      Hiroshima University
    The Study on KL-6 as Morbidity Ornamentation Factor and Prognosis Factor of Idiopathic Interstitial Pneumonia.
    • 批准号：
      14370197
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $8.83万
    • 财政年份：
      2002
    • 负责人：
      KOHNO Nobuoki
    • 依托单位：
      HIROSHIMA UNIVERSITY
    The Establishment of KL-6 Associated New Serum Markers Using High Sensitive Electrochemiluminescence Immunoassay.
    • 批准号：
      13557051
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $9.02万
    • 财政年份：
      2001
    • 负责人：
      KOHNO Nobuoki
    • 依托单位：
      HIROSHIMA UNIVERSITY
    DEVELOPMENT OF A LUNG CANCER TREATMENT USING ANTI-KL-6/MUC1 MULTI-MONOCLONAL ANTIBODIES
    海外基金