Clinical Significance of Anti-MUC1 Natural Autoantibody in Sera from Patients with Lung Cancer

肺癌患者血清中抗 MUC1 天然自身抗体的临床意义

• 批准号: 08670665
• 负责人: KOHNO Nobuoki
• 金额: $ 1.41万
• 依托单位: EHIME UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670665/
• 关键词: LUNG CANCER; NON-SMALL CELL LUNG CANCER; PROGNOSTIC FACTOR; ANTI-MUC1 NATURAL AUTOANYTIBODY; MUC1; KL-6; 自己抗体; 抗MUC1抗体

We found that there are natural autoantibodies against KL-6/MUC1 in sera from healthy volunteers. We tried to clarify the clinical significance of the anti-MUC1 natural autoantibodies in sera from patients with advanced stages of non-small cell lung cancer.Subjects were 9 patients with clinical stage IIIB and 21 patients with clinical stage IV of non-small cell lung cancer. Controls were 60 healthy volunteers.Serum level of the anti-MUC1 natural autoantibodies were 108(]SY.+-。[)25.6 U/ml (mean (]SY.+-。[) SD) in healthy volunteers and 32 (]SY.+-。[) 13 U/ml in lung cancer patients. In the lung cancer patients, theirsurvival time of patients with high serum level of the anti-MUC1 natural autoantibodies more than 32 U/ml was significantly longer than patients with low level of the natural autoantibodies :These results clearly indicate that the serum level of anti-MUC1 natural autoantibodies is a novel prognostic factor for oatients with advanced stages of non-small cell lung cancer and that they might have anti-tumor effects against lung cancer.

我们发现健康志愿者血清中存在抗KL-6/MUC1的天然自身抗体。我们试图阐明晚期非小细胞肺癌患者血清中抗muc1天然自身抗体的临床意义。研究对象为临床IIIB期9例、临床IV期21例非小细胞肺癌患者。对照组为60名健康志愿者。血清抗muc1天然自身抗体水平为108(]SY.+-), 25.6 U/ml(平均（]SY.+-）。[) SD), 32 (]SY.+-。[)肺癌患者13 U/ml。在肺癌患者中，血清中抗muc1天然自身抗体水平高于32 U/ml的患者的生存时间明显高于低水平的患者：这些结果清楚地表明，血清中抗muc1天然自身抗体水平是晚期非小细胞肺癌患者新的预后因素，可能对肺癌具有抗肿瘤作用。

项目成果

Kohno N., et al.: "Comparative studies of CAM 123-6 and carcinoembryonic antigen for the serological detection of pulmonary adenocarcinoma." Cancer Detect Prev. 21. 124-128 (1997)

Kohno N. 等人：“CAM 123-6 和癌胚抗原用于肺腺癌血清学检测的比较研究。”

Kohno N., et al.: "Comparative srudies of CAM 123-6 and carcinoembryonic antigen for the serological detection of pulmonary adenocarcinoma." Cancer Detect Prev. 21. 124-128 (1997)

Kohno N. 等人：“用于肺腺癌血清学检测的 CAM 123-6 和癌胚抗原的比较研究”。

Kohno N,Hirasawa Y,Kondo K,Inoue Y,Fujioka S,Fujino S,Abe M,Yokoyama A,Hiwada K,Watanabe K,Nishimura J.: "Comparative studies of CAM 123-6 and carcinoembryonic antigen for the serological detection of pulmonary adenocarcinoma." Cancer Detect Prev. 21. 124

Kohno N、Hirasawa Y、Kondo K、Inoue Y、Fujioka S、Fujino S、Abe M、Yokoyama A、Hiwada K、Watanabe K、Nishimura J.：“CAM 123-6 和癌胚抗原用于血清学检测的比较研究

Inoue Y., et al.: "Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis." Am J Respin Crit Care Med. 156. 109-115 (1997)

Inoue Y. 等人：“铍沉着症中的肺上皮细胞损伤和肺泡毛细血管通透性。”

Hirasawa Y,Kohno N,Yokoyama A,Inoue Y,Abe M,Hiwada K.: "KL-6, a human MUC1 mucin, is chemotactic for human fibroblasts." Am J Respir Cell Mol Biol. 17. 501-507 (1997)

Hirasawa Y、Kohno N、Yokoyama A、Inoue Y、Abe M、Hiwada K.：“KL-6 是一种人 MUC1 粘蛋白，对人成纤维细胞具有趋化作用。”