Clinical Significance of Anti-MUC1 Natural Autoantibody in Sera from Patients with Lung Cancer

我们发现健康志愿者血清中存在天然的抗KL-6/MUC1自身抗体。为探讨晚期非小细胞肺癌患者血清中抗MUC1天然自身抗体的临床意义，以临床IIIB期9例，临床IV期21例为研究对象。对照组为60例健康志愿者，血清中抗MUC1天然自身抗体水平为108。-.[]25.6U/ml，平均()Sy。-.[SD])和32例健康志愿者(SY)。-.[]肺癌患者为13U/ml。在肺癌患者中，血清抗MUC1天然自身抗体水平高于32U/ml的患者的生存时间明显长于血清天然自身抗体水平低的患者。这些结果表明，血清抗MUC1天然自身抗体水平是晚期非小细胞肺癌患者的一个新的预后因素，它们可能具有抗肺癌的作用。

We found that there are natural autoantibodies against KL-6/MUC1 in sera from healthy volunteers. We tried to clarify the clinical significance of the anti-MUC1 natural autoantibodies in sera from patients with advanced stages of non-small cell lung cancer.Subjects were 9 patients with clinical stage IIIB and 21 patients with clinical stage IV of non-small cell lung cancer. Controls were 60 healthy volunteers.Serum level of the anti-MUC1 natural autoantibodies were 108(]SY.+-。[)25.6 U/ml (mean (]SY.+-。[) SD) in healthy volunteers and 32 (]SY.+-。[) 13 U/ml in lung cancer patients. In the lung cancer patients, theirsurvival time of patients with high serum level of the anti-MUC1 natural autoantibodies more than 32 U/ml was significantly longer than patients with low level of the natural autoantibodies :These results clearly indicate that the serum level of anti-MUC1 natural autoantibodies is a novel prognostic factor for oatients with advanced stages of non-small cell lung cancer and that they might have anti-tumor effects against lung cancer.