Regulation of skin-directed migration of regulatory T cells by fucosyltransferase
Regulation of skin-directed migration of regulatory T cells by fucosyltransferase
批准号:
19390298
负责人:
SHIOHARA Tetsuo
金额:
$12.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
点击翻译按钮获取中文摘要
英文摘要
重要薬疹においては、制御性T細胞(Treg)とエフェクターT細胞(Teff)の相互関係がその臨床型、重症度を決める最大の要因である。そのためTregの機能を如何に高めるかが治療が成功するかどうかの鍵となる。本研究により、最も予後の悪い中毒性表皮壊死症(TEN)の治療として最も有用である血漿交換が、Tregのフコース転移酵素VII(Fuc-TVII)の発現を高めることによりTregを局所に遊走させ病変を治癒に向かせる可能性が明らかになった。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
招聰講演「感染症と薬剤アレルギー」
特邀报告“传染病与药物过敏”
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[矢部博興, 松岡貴志, 朝井廉, 兼子直, 塩原哲夫]
通讯作者:
塩原哲夫
DOI:
--
发表时间:
2009
期刊:
Arch Dermatol (in press)
影响因子:
--
作者:
[T. Kondo, et al, Shiohara T]
通讯作者:
Shiohara T
Exacerbating role of gammadelta T cells in chronic colitis of T-cell receptor alpha mutant mice
γδ T 细胞在 T 细胞受体 α 突变小鼠慢性结肠炎中的加剧作用
DOI:
--
发表时间:
2008
期刊:
Gastroenterology 134
影响因子:
--
作者:
[Nanno M, Inoue N, Hibi T, et. al.]
通讯作者:
et. al.
DOI:
10.1016/j.autrev.2009.02.029
发表时间:
2009-05-01
期刊:
AUTOIMMUNITY REVIEWS
影响因子:
13.6
作者:
[Aota, Noriko, Shiohara, Tetsuo]
通讯作者:
Shiohara, Tetsuo
DOI:
10.1111/j.1365-2230.2009.03622.x
发表时间:
2010-07-01
期刊:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
影响因子:
4.1
作者:
[Mizukawa, Y., Shiohara, T.]
通讯作者:
Shiohara, T.
共 25 条
Analysis of factors that regulate effector T cell and regulatory T cell recruitment to the skin
-
批准号:21390327
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.65万
-
财政年份:2009
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Analysis of mechanisms by which CD8^+ T cells differentiate into the skin-homing phenotype
-
批准号:15390344
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.6万
-
财政年份:2003
-
负责人:SHIOHARA Tetsuo
-
依托单位:
The role for intraepidermal T cells as innate immune cells
-
批准号:13470175
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.32万
-
财政年份:2001
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Mechanisms by which fucosyltransferases regulate epidermotropic migration of T cels
-
批准号:11470184
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$8.06万
-
财政年份:1999
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Significance and regulatory mechanisms of Fas/Fas L expression in the process of epidermal injury mediated by T cells
-
批准号:09470191
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$6.91万
-
财政年份:1997
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Functions and activation mechanisms of epidermal T cells.
-
批准号:06454318
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.67万
-
财政年份:1994
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Molecular mechanism for homing of T cells to the epidermis
-
批准号:04454288
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.35万
-
财政年份:1992
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Analysis of Mechanisms by Which T Cells Migrate to the Epidermis
-
批准号:01480268
-
项目类别:Grant-in-Aid for General Scientific Research (B)
-
资助金额:$4.03万
-
财政年份:1989
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Analysis of factors relevant to the therapies for immunologically mediated skin diseases.
-
批准号:63044130
-
项目类别:Grant-in-Aid for Overseas Scientific Survey.
-
资助金额:$1.6万
-
财政年份:1988
-
负责人:SHIOHARA Tetsuo
-
依托单位:
Analysis of Pathogenesis of lichenoid tissue reactions
-
批准号:62570461
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.22万
-
财政年份:1987
-
负责人:SHIOHARA Tetsuo
-
依托单位:
海外基金