Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells
Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells
批准号:
19390295
负责人:
TAMAI Katsuto
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We demonstrated that detached RDEB epithelia recruit platelet-derived growth factor receptor alpha (PDGFRα)-positive bone marrow cells (PDGFRα+ BMCs) via circulation, and that the PDGFRα+ BMCs contain particular population to provide epithelial cells expressing keratin 5 in the RDEB skin by differentiation of those bone marrow-derived PDGFRα-positive cells. Furthermore, the PDGFRα-positive BMCs were shown to be undifferentiated non-hematopoietic cell populations, and to reside particularly on and around surface of the bone and trabeculae in bone marrow by intravital two-photon imaging.
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Basal keratinocyte-targeting gene delivery system for in vivo EB gene therapy
用于体内 EB 基因治疗的基础角质形成细胞靶向基因递送系统
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y, Katsuto Tamai]
通讯作者:
Katsuto Tamai
DOI:
10.1089/ten.tea.2009.0322
发表时间:
2010-04-01
期刊:
TISSUE ENGINEERING PART A
影响因子:
4.1
作者:
[Kimura, Yu, Miyazaki, Nobuhiko, Tabata, Yasuhiko]
通讯作者:
Tabata, Yasuhiko
Bone marrow stem cell therapy for epidermolysis bullosa
骨髓干细胞治疗大疱性表皮松解症
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y, Katsuto Tamai, Katsuto Tamai]
通讯作者:
Katsuto Tamai
Bone marrow is an essential source of keratinocytes in the grafted skin
骨髓是移植皮肤角质形成细胞的重要来源
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y, Katsuto Tamai, Katsuto Tamai, Katsuto Tamai, Katsuto Tamai]
通讯作者:
Katsuto Tamai
ifferential regulation of karyopherin alpha 2 expression by TGF-β1 and IFN-γin normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1.
正常人表皮角质形成细胞中 TGF-β1 和 IFN-γ 对核转运蛋白 α 2 表达的差异调节:KPNA2 对 IRF-1 核转位的明显贡献。
DOI:
--
发表时间:
2007
期刊:
J Invest Dermatol 25;127
影响因子:
--
作者:
[Umegaki N, Tamai K, Nakano H, Moritsugu R, Yamazaki T, Hanada K, Katayama I, Kaneda Y]
通讯作者:
Kaneda Y
共 29 条
Development of novel therapeutic strategy for skin diseases by utilizing anti-inflammatory activity of circulating mesenchymal stem cells
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批准号:26670531
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:TAMAI Katsuto
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依托单位:
Development of activator for skin function using bone marrow mesenchymal stem cell mobilizer
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批准号:24659530
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:TAMAI Katsuto
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依托单位:
Elucidation of mesenchymal to epithelial transition mechanism of bone marrow mesenchymal stem cells and application to regenerative medicine.
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批准号:22390217
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2010
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负责人:TAMAI Katsuto
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依托单位:
Development of less-invasive in vivo gene delivery system and application to gene therapy for dystrophic epidermolysis bullosa
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批准号:16390317
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.22万
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财政年份:2004
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负责人:TAMAI Katsuto
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依托单位:
Development of gene therapy for dystrophic epidemolysis bullosa with artificial adhension molecule
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批准号:14370257
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.9万
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财政年份:2002
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负责人:TAMAI Katsuto
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依托单位:
The role of POU domain transcription factors in the epidermal development and differentiation
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批准号:10470185
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.96万
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财政年份:1998
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负责人:TAMAI Katsuto
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依托单位:
海外基金