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Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells

Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells
骨髓源性上皮细胞诱导上皮再生的基础研究
批准号:
19390295
负责人:
TAMAI Katsuto
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
We demonstrated that detached RDEB epithelia recruit platelet-derived growth factor receptor alpha (PDGFRα)-positive bone marrow cells (PDGFRα+ BMCs) via circulation, and that the PDGFRα+ BMCs contain particular population to provide epithelial cells expressing keratin 5 in the RDEB skin by differentiation of those bone marrow-derived PDGFRα-positive cells. Furthermore, the PDGFRα-positive BMCs were shown to be undifferentiated non-hematopoietic cell populations, and to reside particularly on and around surface of the bone and trabeculae in bone marrow by intravital two-photon imaging.
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会议论文
Basal keratinocyte-targeting gene delivery system for in vivo EB gene therapy
用于体内 EB 基因治疗的基础角质形成细胞靶向基因递送系统
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y, Katsuto Tamai]
通讯作者: Katsuto Tamai
DOI: 10.1089/ten.tea.2009.0322
发表时间: 2010-04-01
期刊: TISSUE ENGINEERING PART A
影响因子: 4.1
作者: [Kimura, Yu, Miyazaki, Nobuhiko, Tabata, Yasuhiko]
通讯作者: Tabata, Yasuhiko
Bone marrow stem cell therapy for epidermolysis bullosa
骨髓干细胞治疗大疱性表皮松解症
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y, Katsuto Tamai, Katsuto Tamai]
通讯作者: Katsuto Tamai
Bone marrow is an essential source of keratinocytes in the grafted skin
骨髓是移植皮肤角质形成细胞的重要来源
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Shimbo T, Kawachi M, Saga K, Fujita H, Yamazaki T, Tamai K, Kaneda Y, Katsuto Tamai, Katsuto Tamai, Katsuto Tamai, Katsuto Tamai]
通讯作者: Katsuto Tamai
29
    Development of novel therapeutic strategy for skin diseases by utilizing anti-inflammatory activity of circulating mesenchymal stem cells
    • 批准号:
      26670531
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      TAMAI Katsuto
    • 依托单位:
    Development of activator for skin function using bone marrow mesenchymal stem cell mobilizer
    • 批准号:
      24659530
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2012
    • 负责人:
      TAMAI Katsuto
    • 依托单位:
    Elucidation of mesenchymal to epithelial transition mechanism of bone marrow mesenchymal stem cells and application to regenerative medicine.
    • 批准号:
      22390217
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.15万
    • 财政年份:
      2010
    • 负责人:
      TAMAI Katsuto
    • 依托单位:
    Development of less-invasive in vivo gene delivery system and application to gene therapy for dystrophic epidermolysis bullosa
    • 批准号:
      16390317
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.22万
    • 财政年份:
      2004
    • 负责人:
      TAMAI Katsuto
    • 依托单位:
    海外基金