Development of F-18 fluorodeoxymannose (FDM) as a PET probe for cancer imaging
Development of F-18 fluorodeoxymannose (FDM) as a PET probe for cancer imaging
批准号:
19390312
负责人:
FUKUDA Hiroshi
金额:
$7.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We attempted to develop a method for radio-synthesis of ^<18>F-fluorodeoxymannose (^<18>F-FDM) by nucleofilic substituted reaction. We synthesized 3 precursors for ^<18>F-FDM radio-synthesis and ^<18>F-FDM was successfully synthesized using precursor 3 with high radiochemical yield (43-67%) and purity (94-98%). Bio-distribution and imaging studies of tumor bearing rat revealed high tumor uptake, relatively low uptake in the brain and rapid clearance from the kidney and blood. No acute toxicity was found in mice administered with 0.1および1.0mg/kg of cold FDM.
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Influences of nitrogylcelin treatment on tumor uptake of hypoxia marker, [F-18]FRP170
硝化甘油治疗对肿瘤摄取缺氧标志物[F-18]FRP170的影响
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Kaneta T, Iwata R, Fukuda H(11人, 3,10番目)]
通讯作者:
3,10番目)
DOI:
10.1007/s12149-007-0061-8
发表时间:
2007-11-01
期刊:
ANNALS OF NUCLEAR MEDICINE
影响因子:
2.6
作者:
[Minamimoto, Ryogo, Senda, Michio, Inoue, Tomio]
通讯作者:
Inoue, Tomio
私が歩んできた学際的医工学研究の道-PET, BNCT
我的跨学科医学工程研究之路——PET、BNCT
DOI:
--
发表时间:
2008
期刊:
医学物理 28
影响因子:
--
作者:
[鬼塚俊明, 重藤寛史, 大久保善朗, 福田寛]
通讯作者:
福田寛
がん薬物療法におけるポジトロンCTの役割
正电子CT在癌症药物治疗中的作用
DOI:
--
发表时间:
2008
期刊:
山形医学 26
影响因子:
--
作者:
[T. Ito, N. Hayashizaki, T. Ishibashi, T. Hattori, 吉岡 孝志]
通讯作者:
吉岡 孝志
新規前駆体による[^<18>F]FDM合成とその生物学的評価
[^<18>F]使用新前体的FDM合成及其生物学评价
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[新保亮, 岩田錬, 福田寛, (8人, 7,8番目)]
通讯作者:
7,8番目)
共 41 条
Study of computer simulation, computer measurement and image correction for color-vision deficiencies
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批准号:24500212
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
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财政年份:2012
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负责人:FUKUDA Hiroshi
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依托单位:
Development of positron emitter labeled agents for boron neutron capture therapy
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批准号:23650610
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.66万
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财政年份:2011
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负责人:FUKUDA Hiroshi
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Developments of CFRP structures with electricity storagepotential
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批准号:22560683
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2010
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负责人:FUKUDA Hiroshi
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依托单位:
Practical intervention to stakeholder for preventing street crime
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批准号:21530729
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2009
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负责人:FUKUDA Hiroshi
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依托单位:
Study of Isohedral tilings by polyominoes and polyiamonds
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批准号:20540127
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:2008
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负责人:FUKUDA Hiroshi
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依托单位:
Development of basic technology for brain-machine interface applying brain mechanism in visuo-motor transformation
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批准号:20760269
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2008
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负责人:FUKUDA Hiroshi
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依托单位:
A Basic Study on Development of Curriculum and Teaching Methods in Human Rights Education based on Analysis of Council of Europe's Undertakings in the field of Human Rights Education
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批准号:16530564
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:FUKUDA Hiroshi
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依托单位:
International Data Base for Human Brain Function
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批准号:09044250
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.65万
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财政年份:1997
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负责人:FUKUDA Hiroshi
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依托单位:
Development of Nuclear Medicine Technique for the Evaluation of Cell Proliferation Kinetics, Directry Contributing to Cancer Treatment
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批准号:09470196
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$6.14万
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财政年份:1997
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负责人:FUKUDA Hiroshi
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依托单位:
Neurobiological Study for Demintia. -In vivo analysis of human brain using PET.
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批准号:05454297
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.1万
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财政年份:1993
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负责人:FUKUDA Hiroshi
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依托单位:
Research on a New Processing Technology for Advanced Composites
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批准号:04650057
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1992
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负责人:FUKUDA Hiroshi
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依托单位:
Study on mechanism of salivary gland dysfunction in Sjogren's syndrome
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批准号:04454494
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.16万
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财政年份:1992
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负责人:FUKUDA Hiroshi
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依托单位:
Research on Brain Function through in vivo Neuroreceptor Study Using Positron Emission Tomography
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批准号:03670554
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:FUKUDA Hiroshi
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依托单位:
A Study on the formation of Pestalozzi's Thoughts on Moral-Reliqious Education.
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批准号:03610112
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
-
财政年份:1991
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负责人:FUKUDA Hiroshi
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依托单位:
Ultrasonography of Parotid and Submandibular Glands in Sjogren's Syndrome
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批准号:63570925
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1988
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负责人:FUKUDA Hiroshi
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依托单位: