International Data Base for Human Brain Function

1.计算机脑图谱系统的研制与评价我们用Zilles等与我们合作开发的弹性变换系统验证了空间标准化的解剖精度。我们发现，与其他系统相比，该系统在空间归一化过程中表现出较高的效率，表明它不仅可以用于正电子发射断层扫描（PET）激活研究，而且可以用于功能磁共振成像（MRI）研究.认知和运动功能的脑功能图罗兰的小组和我们的小组参与了这个项目。我们使用PET来研究人类参与多种认知或运动任务的功能性大脑区域。所得结果作为本课题组正在开发的脑功能数据库的内容.国际脑解剖数据库的开发我们和Evans的小组在蒙特利尔举行了一次会议，并同意与Zilles的小组建立可比较的国际脑解剖数据库。我们决定为每组校正300名健康受试者的3D脑MRI，并使用Evans小组开发的空间归一化技术进行种族间比较。我们的小组已经校正了150个脑MRI，我们已经从这些数据中估计了日本不同年龄组人群的标准脑解剖结构。

1. Development and Evaluation of the Computerized Brain Atlas SystemWe validated the anatomical precision of spatial normalization with the Elastic Transformation System which has developed by Zilles's group with our collaboration. We found that this system shows high effectiveness in spatial normalization procedure compared with other systems, indicating that it can be used not only for positorn emission tomography (PET) activation studies but for functional magnetic resonance imaging (MRI) studies.2. Functional Brain Mapping of Cognitive and Motor FunctionRoland's group and our group participated this project. We used PET to investigate functional brain areas of humans involved in many kinds of cognitive or motor tasks. The results obtained are used as contents of the brain function database which has been developing by our group.3. Development of International Brain Anatomy DatabaseWe and Evans's group had a meeting in Montreal, and have agreed to create comparable international brain anatomy database with Zilles's group. We have decided to correct 300 3D-brain MRI of healthy subjects for each group, and to perform inter-ethnic comparisons using spatial normalization technique develped by Evans's group. Our group already corrected 150 brain MRIs, and we have estimated standard brain anatomy of the Japanese population of different age group from this data.