International Data Base for Human Brain Function

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1. Development and Evaluation of the Computerized Brain Atlas SystemWe validated the anatomical precision of spatial normalization with the Elastic Transformation System which has developed by Zilles's group with our collaboration. We found that this system shows high effectiveness in spatial normalization procedure compared with other systems, indicating that it can be used not only for positorn emission tomography (PET) activation studies but for functional magnetic resonance imaging (MRI) studies.2. Functional Brain Mapping of Cognitive and Motor FunctionRoland's group and our group participated this project. We used PET to investigate functional brain areas of humans involved in many kinds of cognitive or motor tasks. The results obtained are used as contents of the brain function database which has been developing by our group.3. Development of International Brain Anatomy DatabaseWe and Evans's group had a meeting in Montreal, and have agreed to create comparable international brain anatomy database with Zilles's group. We have decided to correct 300 3D-brain MRI of healthy subjects for each group, and to perform inter-ethnic comparisons using spatial normalization technique develped by Evans's group. Our group already corrected 150 brain MRIs, and we have estimated standard brain anatomy of the Japanese population of different age group from this data.