Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
批准号:
19390342
负责人:
FUJIMOTO Jiro
金额:
$11.9万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
Abdominal adhesion formation is constituted after abdominal surgery, and it may cause abdominal pain, bowel obstruction and infertile. Since the mechanism has been still unclear, we established a unique experimental model of adhesion, and elucidated the related molecules which are inflammatory cytokine, interferon-γ, and fibrolytic factor, plasminogen activator inhibitor-1. Furthermore, we could reduce the adhesion to inhibit these molecules using recombinant hepatocyte growth factor, providing a new way to prevent postoperative adhesions.
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NKT cell-driven IFN-γ plays an important role in postoperative adhesion formation.
NKT细胞驱动的IFN-γ在术后粘连形成中发挥重要作用。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Kosaka H, Fujimoto J]
通讯作者:
Fujimoto J
Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation Nature Medicine
干扰素-γ是预防术后粘连形成的治疗靶分子 Nature Medicine
DOI:
--
发表时间:
2008
期刊:
14
影响因子:
--
作者:
[Kosaka H, Fujimoto J, et al.]
通讯作者:
et al.
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kosaka H, Fujimoto J, et al.]
通讯作者:
et al.
術後癒着形成はIFN-g/STAT1依存性のPAI亢進による
术后粘连形成是由于 IFN-g/STAT1 依赖性 PAI 增强所致
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[青木浩樹, 吉村耕一, 松崎益徳, 小坂久,藤元治朗]
通讯作者:
小坂久,藤元治朗
Brand-new prevention method of postoperative adhesion formation used by HGF.
HGF采用的全新预防术后粘连形成的方法。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kosaka H, Fujimoto J]
通讯作者:
Fujimoto J
共 13 条
Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"
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批准号:23659660
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2011
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负责人:FUJIMOTO Jiro
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依托单位:
Analysis of molecular mechanism and the regulation of adhesion
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批准号:22390250
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2010
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负责人:FUJIMOTO Jiro
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依托单位:
Analysis of the role of angiogenesis and non-parenchymal cells during hepatic regeneration.
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批准号:17390375
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2005
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负责人:FUJIMOTO Jiro
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依托单位:
Angiogenesis and tumor dormancy therapy in gynecological cancer
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批准号:14370528
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.62万
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财政年份:2002
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负责人:FUJIMOTO Jiro
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依托单位:
Basic research and clinical approach of molecular therapy for liver cirrhosis and HCC
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批准号:14370395
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.62万
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财政年份:2002
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负责人:FUJIMOTO Jiro
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依托单位:
Functional analysis of LATS protein kinases, products of novel tumor-suppressor genes
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批准号:12670130
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.6万
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财政年份:2000
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负责人:FUJIMOTO Jiro
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依托单位:
GENE THERAPY OF LIVER CIRRHOSIS ; BASIC RESEARCH AND A PROSPECT FOR CLINICAL TRIAL
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批准号:11470266
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.9万
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财政年份:1999
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负责人:FUJIMOTO Jiro
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依托单位:
Angiogenesis in female genital tract cancers and its inhibition
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批准号:11671606
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:FUJIMOTO Jiro
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依托单位:
Functional analysis of FAK tyrosine kinase in intracellular signaling pathways
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批准号:09680668
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.9万
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财政年份:1997
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负责人:FUJIMOTO Jiro
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依托单位:
Study of endocrinological contribution for invasion and metastasis in gynecological cancers
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批准号:08671881
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1996
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负责人:FUJIMOTO Jiro
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依托单位:
In vivo gene transduction in hepatoma using monoclonal antibody or specific promotor.
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批准号:07457282
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.8万
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财政年份:1995
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负责人:FUJIMOTO Jiro
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依托单位:
Study of mechanisms of development and growth in hormone (especially estrogen) dependent uterine tumor and its related diseases.
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批准号:06671638
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.09万
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财政年份:1994
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负责人:FUJIMOTO Jiro
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依托单位:
Difference of sensitivity to the chemoprevention (cisplatin vs.cv-3611 or SOD) between young and gerontic mice
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批准号:06671269
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.26万
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财政年份:1994
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负责人:FUJIMOTO Jiro
-
依托单位:
Suppression ofdevelopment of spontaneous and cisplatin-induced malignant
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批准号:04670779
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项目类别:Grant-in-Aid for Scientific Research (C).
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资助金额:$0.45万
-
财政年份:1992
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负责人:FUJIMOTO Jiro
-
依托单位:
Effects of recombinant human superoxide dismutase and 2-0-octadecylascorbic acid on survival of tumor bearing mice and on side effects of bleomycin and adriamycin
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批准号:63570633
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.45万
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财政年份:1988
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负责人:FUJIMOTO Jiro
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依托单位:
Difference in histologic effects on the liver with regard to the route of administration of fluorinated pyrimidines in gastric cancer patients
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批准号:60570624
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.77万
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财政年份:1985
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负责人:FUJIMOTO Jiro
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依托单位:
海外基金