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Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion

Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
实验性手术粘连模型的建立及器官粘连免疫机制分析
批准号:
19390342
负责人:
FUJIMOTO Jiro
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
Abdominal adhesion formation is constituted after abdominal surgery, and it may cause abdominal pain, bowel obstruction and infertile. Since the mechanism has been still unclear, we established a unique experimental model of adhesion, and elucidated the related molecules which are inflammatory cytokine, interferon-γ, and fibrolytic factor, plasminogen activator inhibitor-1. Furthermore, we could reduce the adhesion to inhibit these molecules using recombinant hepatocyte growth factor, providing a new way to prevent postoperative adhesions.
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会议论文
NKT cell-driven IFN-γ plays an important role in postoperative adhesion formation.
NKT细胞驱动的IFN-γ在术后粘连形成中发挥重要作用。
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Kosaka H, Fujimoto J]
通讯作者: Fujimoto J
Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation Nature Medicine
干扰素-γ是预防术后粘连形成的治疗靶分子 Nature Medicine
DOI: --
发表时间: 2008
期刊: 14
影响因子: --
作者: [Kosaka H, Fujimoto J, et al.]
通讯作者: et al.
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kosaka H, Fujimoto J, et al.]
通讯作者: et al.
術後癒着形成はIFN-g/STAT1依存性のPAI亢進による
术后粘连形成是由于 IFN-g/STAT1 依赖性 PAI 增强所致
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [青木浩樹, 吉村耕一, 松崎益徳, 小坂久,藤元治朗]
通讯作者: 小坂久,藤元治朗
13
    Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"
    • 批准号:
      23659660
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2011
    • 负责人:
      FUJIMOTO Jiro
    • 依托单位:
    Analysis of molecular mechanism and the regulation of adhesion
    • 批准号:
      22390250
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.15万
    • 财政年份:
      2010
    • 负责人:
      FUJIMOTO Jiro
    • 依托单位:
    Analysis of the role of angiogenesis and non-parenchymal cells during hepatic regeneration.
    • 批准号:
      17390375
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.54万
    • 财政年份:
      2005
    • 负责人:
      FUJIMOTO Jiro
    • 依托单位:
    Angiogenesis and tumor dormancy therapy in gynecological cancer
    • 批准号:
      14370528
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.62万
    • 财政年份:
      2002
    • 负责人:
      FUJIMOTO Jiro
    • 依托单位:
    海外基金