Difference of sensitivity to the chemoprevention (cisplatin vs.cv-3611 or SOD) between young and gerontic mice

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Difference of suppressive effects of a scavenger of the active oxygen species, 2-0-octadecyl ascorbic acid (CV-3611), on development of spontaneous (sp.) and cisplatin (CDDP)-induced malignant tumors between young and gerontic C3H/He mice.The incidence of tumor was significantly (sg.) higher and mean survival time sg.lower in female mice intraperitoneally injected with 10 times 2 mg/kg CDDP than in the control group, while incidence of tumor was lower and survival time longer in female mice subcutaneously (sc) injected with 10 times 5 mg/kg CV-3611 than in the control group. Mice injected with both CV-3611 and CDDP showed lower tumor incidence and sg.longer survival time than those injected with CDDP alone.Male mice showed the same tendency as female in function of CDDP and CV-3611. Tumor-inducing ability of CDDP in gerontic mice was the same as in young mice, but suppressive effects of CV-3611 in gerontic mice slight.Effects of SOD or CV-3611 on sp.and CDDP-induced carcinogenesis in young C3H/He mice.Cv-3611 (total dose, 50 mg/kg) sg.suppressed and delayd sp.and CDDP-induced malignant tumors in mice. However, in the case of the mice which survived to times 2 mg/kg SOD sc with or without CDDP,suppression and delay of sp.and CDDP-induced carcinogenesis was slight in the male mice, but carcinogenesis was rather enhanced in female mice.