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Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"

Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"
“凝血、IFNγ和PAI-1控制肝纤维化和癌变机制”假说的提出和验证
批准号:
23659660
负责人:
FUJIMOTO Jiro
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
We elucidated that blood coagulation system and IFN-γ(Interferon-gamma), PAI-1(Plasminogen activator inhibitor-1) controlled the adhesion, desmoplasia by operation adhesion mechanism analysis. From this analysis, we hypothesized that blood coagulation system, IFN-γ, PAI-1 played an important role in liver fibrosis and inspected it by the PAI-1 knockout mice, and it was suggested that PAI-1 and t-PA (tissue plasminogen activator) affected liver fibrosis but IFN-γ did not contribute so much using a mouse model that was ligated bile duct.
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Analysis of molecular mechanism and the regulation of adhesion
  • 批准号:
    22390250
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $12.15万
  • 财政年份:
    2010
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
  • 批准号:
    19390342
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.9万
  • 财政年份:
    2007
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
Analysis of the role of angiogenesis and non-parenchymal cells during hepatic regeneration.
  • 批准号:
    17390375
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $9.54万
  • 财政年份:
    2005
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
Angiogenesis and tumor dormancy therapy in gynecological cancer
  • 批准号:
    14370528
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $7.62万
  • 财政年份:
    2002
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
国内基金
海外基金
内皮细胞源性CXCL10介导IFN-γ依赖性巨噬细胞代谢重编程在抗汉塞巴尔通体感染中的作用机制研究
KW6002通过调控IFN-γ炎症通路及类淋巴功能改善MS-ON病理的机制研究
IFN-γ微球经肝动脉递送协同PD-1抑制剂抗肝癌的增效机制与免疫微环境重塑
  • 批准号:
    2026JJ80633
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    王小军
  • 依托单位:
IFN-γ信号激活通过自噬缓解CDDP诱导的心脏毒性
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    曹莹莹
  • 依托单位: