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Analysis of molecular mechanism and the regulation of adhesion

Analysis of molecular mechanism and the regulation of adhesion
分子机制分析及粘附调控
批准号:
22390250
负责人:
FUJIMOTO Jiro
金额:
$12.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

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中文摘要
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英文摘要
We analyzed the adhesion formation after hepatectomy in mice and humans. After hepatectomy, NKT cells in the liver accumulated nearby cut end and produced IFN-γ. Hepatocyte produced PAI-1, fibrinolysis factor, dependent on IFN-γproduction. These molecules are crucial role for adhesion formation after hepatectomy. Mice treated with recombinant HGF was decreased adhesion formation after hepatectomy though inhibition both IFN-γand PAI-1 production. This treatment may apply for the adhesions in human cases in near future.
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Hepatocyte growth factor inhibited adhesion formation after hepatectomy by regulating interferon-gamma and plasminogen activator inhibitor-1 in mice
肝细胞生长因子通过调节干扰素-γ和纤溶酶原激活剂抑制剂-1抑制小鼠肝切除术后粘连形成
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [大橋浩一郎, 藤元治朗, ほか, 根岸淳, 大橋浩一郎]
通讯作者: 大橋浩一郎
IFN-γ derived from NKT cells and plasminogen activator inhibitor-1 (PAI-1) regulate adhesion formation after hepatectomy
NKT 细胞衍生的 IFN-γ 和纤溶酶原激活剂抑制剂-1 (PAI-1) 调节肝切除术后粘附形成
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [犬伏 正幸, 他, 南本亮吾, 大橋 浩一郎]
通讯作者: 大橋 浩一郎
Hepatocyte growth factor prevented abdominal adhesion formation after hepatectomy by regulating interferon-γ and plasminogen activator inhibitor-1
肝细胞生长因子通过调节干扰素-γ和纤溶酶原激活剂抑制剂-1预防肝切除术后腹腔粘连形成
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [大橋浩一郎, 藤元治朗, ほか]
通讯作者: ほか
Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"
  • 批准号:
    23659660
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.33万
  • 财政年份:
    2011
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
Establishment of experimental surgical adhesion model and analysis of immunological mechanism underlying organ adhesion
  • 批准号:
    19390342
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.9万
  • 财政年份:
    2007
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
Analysis of the role of angiogenesis and non-parenchymal cells during hepatic regeneration.
  • 批准号:
    17390375
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $9.54万
  • 财政年份:
    2005
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位:
Angiogenesis and tumor dormancy therapy in gynecological cancer
  • 批准号:
    14370528
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $7.62万
  • 财政年份:
    2002
  • 负责人:
    FUJIMOTO Jiro
  • 依托单位: