Impaired scaffold formation of AQP5 during aging : in the relation with mastication and swallowing

为了让我们即使变老也能过上健康、健康的社会生活，我们研究了AQP5和支架蛋白在老年性口干症发病机制中的作用。我们开发了一种口干症诊断试剂盒，使用唾液中的AQP5。我们检查了咀嚼/吞咽能力受损是否与降低我们通过试剂盒获得的价值有关。植物神经酰胺能减少AQP5的转运，增加AQP5对基质膜的错配。

In order to spend a sane social life with the high quality even if we grow old, we investigate mechanism of pathogenesis of xerostomia caused by aging in relation with AQP5 and scaffold proteins. We developed a diagnostic kit of xerostomia using AQP5 in saliva. We examined whether the impaired mastication/swallowing ability linked decreasing the value that we obtained with the kit. The decreasing of AQP5 trafficking and the enhancement of AQP5 mistrafficking to basal plasma membrane were improved by administration of plant ceramide.