Analysis of physiological functions of the fission yeast ammonium transporters

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In microorganisms and plants, ammonium is an important nitrogen source that is used for amino acid synthesis. Microorganisms and plants have mechanisms of its uptake. In this study, fission yeast was used as a model to elucidate physiological functions of ammonium transporter, which mediate transport of ammonium across the membrane. It has been found that ammonium transporter plays a role not only in uptake of ammonium from the environment but also in morphological differentiation from yeast to filamentous form induced by low ammonium and retention of intracellular ammonium produced from metabolism.