Nicotine-induced remodeling of synapse in hippocampal neuron.
Nicotine-induced remodeling of synapse in hippocampal neuron.
批准号:
19590247
负责人:
TANAKA Hidekazu
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
Nicotine was discovered to induce synaptic remodeling. The remodeling of dendritic spine, the postsynaptic structure, was visualized with green fluorescent protein (GFP) in cultured hippocampal neurons. One-two hours after the application of nicotine, a several micrometer-long filopodia protruded from the head of mushroom-shaped spine. This unique remodeling of spine head suggests a kind of the destabilization of synaptic connection, which may result in the rewiring of neural circuit. This phenomenon might be one of the mechanisms underlying the nicotine addiction.
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DOI:
--
发表时间:
2007
期刊:
Eur J Neurosci 26
影响因子:
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作者:
[Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K, Taguchi A]
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DOI:
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发表时间:
2009
期刊:
J Neurosci Res. 87
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[Yagita Y, Sakurai T, Tanaka H, Kitagawa K, Colman DR, Shan W.]
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DOI:
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发表时间:
2009
期刊:
Biochem Biophys Res Commun. 390
影响因子:
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作者:
[Sugimoto K, Okamura K, Tanaka H, Takashima S, Ochi H, Yamamoto T, Matoba R.]
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Matoba R.
海馬神経細胞接着分子N-cadherin結合蛋白質の網羅的解析
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DOI:
--
发表时间:
2010
期刊:
影响因子:
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作者:
[田中秀和, ほか]
通讯作者:
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DOI:
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发表时间:
2009
期刊:
Biochem J. 417
影响因子:
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[Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, Kanai Y.]
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Kanai Y.
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