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Nicotine-induced remodeling of synapse in hippocampal neuron.

Nicotine-induced remodeling of synapse in hippocampal neuron.
尼古丁诱导海马神经元突触重塑。
批准号:
19590247
负责人:
TANAKA Hidekazu
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010

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项目成果

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中文摘要
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英文摘要
Nicotine was discovered to induce synaptic remodeling. The remodeling of dendritic spine, the postsynaptic structure, was visualized with green fluorescent protein (GFP) in cultured hippocampal neurons. One-two hours after the application of nicotine, a several micrometer-long filopodia protruded from the head of mushroom-shaped spine. This unique remodeling of spine head suggests a kind of the destabilization of synaptic connection, which may result in the rewiring of neural circuit. This phenomenon might be one of the mechanisms underlying the nicotine addiction.
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会议论文
Granulocyte colony-stimulating factor has a negative effect on stroke ou tcome in a muririe model
粒细胞集落刺激因子对 muririe 模型中的卒中结果有负面影响
DOI: --
发表时间: 2007
期刊: Eur J Neurosci 26
影响因子: --
作者: [Yasuda S, Tanaka H, Sugiura H, Okamura K, Sakaguchi T, Tran U, Takemiya T, Mizoguchi A, Yagita Y, Sakurai T, De Robertis EM, Yamagata K, Taguchi A]
通讯作者: Taguchi A
N-cadherin regulates differentiation of neural precursor cells.
N-钙粘蛋白调节神经前体细胞的分化。
DOI: --
发表时间: 2009
期刊: J Neurosci Res. 87
影响因子: --
作者: [Yagita Y, Sakurai T, Tanaka H, Kitagawa K, Colman DR, Shan W.]
通讯作者: Shan W.
Methanphetamine directly accelerates beating rate in cardiomyocytes by increasing Ca2+ entry via L-type Ca2+ channel.
甲基苯丙胺通过 L 型 Ca2 通道增加 Ca2 进入,直接加速心肌细胞的跳动速率。
DOI: --
发表时间: 2009
期刊: Biochem Biophys Res Commun. 390
影响因子: --
作者: [Sugimoto K, Okamura K, Tanaka H, Takashima S, Ochi H, Yamamoto T, Matoba R.]
通讯作者: Matoba R.
海馬神経細胞接着分子N-cadherin結合蛋白質の網羅的解析
海马神经元粘附分子N-钙粘蛋白结合蛋白综合分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [田中秀和, ほか]
通讯作者: ほか
20
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    • 批准号:
      20K05156
    • 项目类别:
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    • 资助金额:
      $2.75万
    • 财政年份:
      2020
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      TANAKA Hidekazu
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    • 项目类别:
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    • 资助金额:
      $2.5万
    • 财政年份:
      2014
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      Grant-in-Aid for Young Scientists (B)
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      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
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    • 财政年份:
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    • 负责人:
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    • 依托单位:
    海外基金