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A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors

A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors
胃肠道间质瘤分子靶向药物继发耐药机制研究
批准号:
19590410
负责人:
HIROTA Seiichi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
We first reported that an imatinib-secondary resistant lesion had secondary c-kit gene mutation in addition to primary c-kit gene mutation. Through analysis of many imatinib-secondary resistant lesions, 70 to 80% of them were proved to have secondary c-kit gene mutations in addition to primary c-kit gene mutations. Most of the secondary c-kit gene mutations were present at exon 13 or exon 17.
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会议论文
Abberant expression of glycosylation in juvenile gastrointestinal stromal tumors
幼年胃肠道间质瘤中糖基化的异常表达
DOI: --
发表时间: 2008
期刊: Proteomics Clin Appl 2
影响因子: --
作者: [T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T]
通讯作者: Nishida T
DOI: 10.1053/j.gastro.2008.01.081
发表时间: 2008-05-01
期刊: GASTROENTEROLOGY
影响因子: 29.4
作者: [Koma, Yu-Ichiro, Furuno, Tadahide, Ito, Akihk]
通讯作者: Ito, Akihk
DOI: 10.1111/j.1440-1827.2009.02370.x
发表时间: 2009-05-01
期刊: PATHOLOGY INTERNATIONAL
影响因子: 2.2
作者: [Masuzawa, Naoko, Kishimoto, Mitsuo, Yanagisawa, Akio]
通讯作者: Yanagisawa, Akio
Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment : a case report.
术前伊马替尼治疗后食管胃肠道间质瘤的手术切除:病例报告。
DOI: --
发表时间: 2010
期刊: Esophagus 7
影响因子: --
作者: [H amada S, Itami A, Watanabe G, Nakayama S, Tanaka E, Hojo M, Yoshizawa A, Hirota S, Sakai Y, Sato H]
通讯作者: Sato H
31
    Influence of various types of receptor tyrosine kinase gene mutations in pathogenesis of GISTs
    • 批准号:
      23390094
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $12.65万
    • 财政年份:
      2011
    • 负责人:
      HIROTA Seiichi
    • 依托单位:
    Analysis of abnormal signaling through KIT and PDGFRA in development of gastrointestinal stromal tumors
    • 批准号:
      17013082
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $30.08万
    • 财政年份:
      2005
    • 负责人:
      HIROTA Seiichi
    • 依托单位:
    Pathological analysis of GIST using transgenic or knock-in-mouse
    Analysis of familial and multiple GIST
    海外基金