A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors
A study of secondary resistance mechanism for molecular target drugs in gastrointestinal stromal tumors
批准号:
19590410
负责人:
HIROTA Seiichi
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We first reported that an imatinib-secondary resistant lesion had secondary c-kit gene mutation in addition to primary c-kit gene mutation. Through analysis of many imatinib-secondary resistant lesions, 70 to 80% of them were proved to have secondary c-kit gene mutations in addition to primary c-kit gene mutations. Most of the secondary c-kit gene mutations were present at exon 13 or exon 17.
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DOI:
--
发表时间:
2008
期刊:
Proteomics Clin Appl 2
影响因子:
--
作者:
[T akahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T]
通讯作者:
Nishida T
DOI:
10.1053/j.gastro.2008.01.081
发表时间:
2008-05-01
期刊:
GASTROENTEROLOGY
影响因子:
29.4
作者:
[Koma, Yu-Ichiro, Furuno, Tadahide, Ito, Akihk]
通讯作者:
Ito, Akihk
DOI:
10.1111/j.1440-1827.2009.02370.x
发表时间:
2009-05-01
期刊:
PATHOLOGY INTERNATIONAL
影响因子:
2.2
作者:
[Masuzawa, Naoko, Kishimoto, Mitsuo, Yanagisawa, Akio]
通讯作者:
Yanagisawa, Akio
Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment : a case report.
术前伊马替尼治疗后食管胃肠道间质瘤的手术切除:病例报告。
DOI:
--
发表时间:
2010
期刊:
Esophagus 7
影响因子:
--
作者:
[H amada S, Itami A, Watanabe G, Nakayama S, Tanaka E, Hojo M, Yoshizawa A, Hirota S, Sakai Y, Sato H]
通讯作者:
Sato H
A mouse model of human GIST.
人类胃肠道间质瘤的小鼠模型。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S, Nishida T, Nishida T, Yamamoto S, Segawa E, Hirota S, Hirota S]
通讯作者:
Hirota S
共 31 条
Influence of various types of receptor tyrosine kinase gene mutations in pathogenesis of GISTs
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批准号:23390094
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.65万
-
财政年份:2011
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负责人:HIROTA Seiichi
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依托单位:
Analysis of abnormal signaling through KIT and PDGFRA in development of gastrointestinal stromal tumors
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批准号:17013082
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$30.08万
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财政年份:2005
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负责人:HIROTA Seiichi
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依托单位:
Pathological analysis of GIST using transgenic or knock-in-mouse
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批准号:13214058
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$21.95万
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财政年份:2002
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负责人:HIROTA Seiichi
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依托单位:
Analysis of familial and multiple GIST
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批准号:14370076
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.49万
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财政年份:2002
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负责人:HIROTA Seiichi
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依托单位:
Generation of gene-targetting mice with gain-of-function mutation of c-kit gene
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批准号:12670203
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.62万
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财政年份:2000
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负责人:HIROTA Seiichi
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依托单位:
Development of practically usefull Ws/Ws rat and its utilization
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批准号:10558121
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.32万
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财政年份:1998
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负责人:HIROTA Seiichi
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依托单位:
Relation between gain-of-function mutation of c-kit gene and development of GIST
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批准号:10670204
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:1998
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负责人:HIROTA Seiichi
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依托单位:
海外基金