Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal
Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal
批准号:
19590411
负责人:
ISOZAKI Koji
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
CADM1 is an adhesion molecule mediating nerve-mast cell interactions. It was demonstrated that both CADM1 protein and mRNA expressed in GISTs of human small intestine but not in GISTs of human stomach. These results suggested that types of ICCs which are considered to be an origin of GISTs are different between gastric and intestinal GISTs.
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Characterization of tyrosine kinase I domain o-kit gene mutation Asn655Lys Newly found in primary jejunal gastrointestinal stromal tumor
原发性空肠胃肠道间质瘤中新发现的酪氨酸激酶I结构域o-kit基因突变Asn655Lys的表征
DOI:
--
发表时间:
2007
期刊:
Am J Gastroenterol 102
影响因子:
--
作者:
[Isozaki K, Nakai N, Hirota S, Takahashi T, Nakai N, Kinoshita K]
通讯作者:
Kinoshita K
Molecular mechanism and morphology in cancer
癌症的分子机制和形态学
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Isozaki K, Hirota S.]
通讯作者:
Hirota S.
DOI:
10.1158/1535-7163.mct-08-0884
发表时间:
2009-01-01
期刊:
MOLECULAR CANCER THERAPEUTICS
影响因子:
5.7
作者:
[Sakurama, Kazufumi, Noma, Kazuhiro, Naomoto, Yoshio]
通讯作者:
Naomoto, Yoshio
A mouse model of human GIST.
人类胃肠道间质瘤的小鼠模型。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[S akamoto K, Sakurai S, Kanda T, Sakuma Y, Hishima T, Hironaka M, Bamba T, Keira Y, Takano Y, Niki T, Hasegawa T, Hirota S, Nishida T, Nishida T, Yamamoto S, Segawa E, Hirota S, Hirota S]
通讯作者:
Hirota S
A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.
通过敲入策略生成具有 KIT-Asp820Tyr 突变的人类多 GIST 家族小鼠模型。
DOI:
--
发表时间:
2007
期刊:
J Pathol. 214
影响因子:
--
作者:
[Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T., Nakai N]
通讯作者:
Nakai N
共 11 条
Analysis of gene expression on interstitial cells of Cajal
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批准号:24590494
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
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财政年份:2012
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负责人:ISOZAKI Koji
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依托单位:
海外基金