Analysis of the molecular mechanism in gastrointestinal pacemaker cell using KIT knock-in animal

KIT基因敲入动物胃肠起搏细胞分子机制分析

• 批准号: 19590411
• 负责人: ISOZAKI Koji
• 金额: $ 2.75万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590411/
• 关键词: 多発性GIST; ノックインマウス; カハールの介在細胞; c-kit遺伝子; 生殖系列; 機能獲得性突然変異; 遺伝子改変動物; 消化管運動; ペースメーカー; KIT; 多発製GIST; ノッタインマウス; exon 17; exon17

CADM1 is an adhesion molecule mediating nerve-mast cell interactions. It was demonstrated that both CADM1 protein and mRNA expressed in GISTs of human small intestine but not in GISTs of human stomach. These results suggested that types of ICCs which are considered to be an origin of GISTs are different between gastric and intestinal GISTs.

CADM 1是介导神经-肥大细胞相互作用的粘附分子。结果表明，CADM 1蛋白和mRNA在人小肠GISTs中均有表达，而在人胃GISTs中无表达。这些结果表明，被认为是GIST起源的ICC类型在胃和肠GIST之间是不同的。

项目成果

Characterization of tyrosine kinase I domain o-kit gene mutation Asn655Lys Newly found in primary jejunal gastrointestinal stromal tumor

原发性空肠胃肠道间质瘤中新发现的酪氨酸激酶I结构域o-kit基因突变Asn655Lys的表征

• 发表时间: 2007
• 期刊: Am J Gastroenterol 102
• 作者: Isozaki K;Nakai N;Hirota S;Takahashi T;Nakai N;Kinoshita K
• 通讯作者: Kinoshita K

Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor

• DOI: 10.1158/1535-7163.mct-08-0884
• 发表时间: 2009-01-01
• 期刊: MOLECULAR CANCER THERAPEUTICS
• 影响因子: 5.7
• 作者: Sakurama, Kazufumi;Noma, Kazuhiro;Naomoto, Yoshio
• 通讯作者: Naomoto, Yoshio

Molecular mechanism and morphology in cancer

癌症的分子机制和形态学

• 发表时间: 2010
• 作者: Isozaki K;Hirota S.
• 通讯作者: Hirota S.

A mouse model of human GIST.

人类胃肠道间质瘤的小鼠模型。

• 发表时间: 2008
• 作者: S akamoto K;Sakurai S;Kanda T;Sakuma Y;Hishima T;Hironaka M;Bamba T;Keira Y;Takano Y;Niki T;Hasegawa T;Hirota S;Nishida T;Nishida T;Yamamoto S;Segawa E;Hirota S;Hirota S
• 通讯作者: Hirota S

A mouse model of human multiple GIST family with KIT-Asp820Tyr mutation generated by knock-in strategy.

通过敲入策略生成具有 KIT-Asp820Tyr 突变的人类多 GIST 家族小鼠模型。

• 发表时间: 2007
• 期刊: J Pathol. 214
• 作者: Takahashi T;Nakajima K;Nishitani A;Souma Y;Hirota S;Sawa Y;Nishida T.;Nakai N
• 通讯作者: Nakai N