The prevalence of insulin resistance and obesity and their correlation in school-age children

学龄儿童胰岛素抵抗和肥胖的患病率及其相关性

基本信息

批准号：
19590600
负责人：
NISHIMURA Rimei
金额：
$ 2.75万
依托单位：
Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2007
资助国家：
日本
起止时间：
2007 至 2010
项目状态：
已结题

项目摘要

Tsunan town is counted among the leading "longevity towns" in Niigata prefecture, Japan. Of the junior school 3rd graders (14 to 15 years old) participating in the health check-up program (participation rate : 100%) sponsored by the town in 2009-10, 157 (86 males and 71 females) were included in this study. Fasting blood samples were taken from the subjects to examine the presence of insulin resistance. Homeostasis model assessment as an index of insulin resistance (HOMA-IR) was calculated based on their fasting insulin and glucose levels. Presence of insulin resistance was defined as a HOMA-IR of 2.5 or greater, and presence of obesity defined by BMI (22.96 or greater for males and 23.66 or greater for females). The percentage of those who met either definition was investigated for each sex.Nine males (10.6%) versus 12 females (16.9%) were diagnosed as insulin-resistant, while 8 males (9.4%) versus 7 females (9.9%) were diagnosed as obese, with 3 each (3.5% versus 4.2%) diagnosed as both insulin-resistant and obese in either sex.In a survey involving virtually all the junior high school 3rd grader residents in a local town, the frequency of individuals diagnosed as insulin-resistant or obese was shown to be about 10% among the children of each sex. However, the diagnoses of insulin resistance and obesity were found not necessarily consistent in both males and females.

海啸镇被视为日本尼加塔县领先的“长寿城镇”。在这项研究中包括该镇在2009 - 10年度赞助的健康检查计划（参与率：100％）的三年级学生中，其中包括157名（86名男性和71名女性）。从受试者中采集空腹血液样本，以检查胰岛素抵抗的存在。稳态模型评估是基于禁食胰岛素和葡萄糖水平计算的胰岛素抵抗指数（HOMA-IR）。胰岛素抵抗的存在定义为2.5或更高的HOMA-IR，BMI定义的肥胖症（男性为22.96或更高，女性为23.66或更高）。 The percentage of those who met either definition was investigated for each sex.Nine males (10.6%) versus 12 females (16.9%) were diagnosed as insulin-resistant, while 8 males (9.4%) versus 7 females (9.9%) were diagnosed as obese, with 3 each (3.5% versus 4.2%) diagnosed as both insulin-resistant and obese in either sex.In a survey involving virtually all the在当地一个城镇的三年级居民，在每个性别的孩子中，被诊断为耐胰岛素或肥胖的个体的频率约为10％。但是，发现胰岛素抵抗和肥胖的诊断在男性和女性中都不一定是一致的。