A mathematical model of calcium signalling in single cells and in multicellular systems

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Calcium released from stores inside cells plays a vital signalling role in living organisms. It initiates cell division after fertilization, mediates communication and learning in the nervous system, causes contraction in the muscular walls of arteries and plays an important but as yet poorly understood role in the information processing that occurs in systems of coupled glial cells. We will construct a unified mathematical model of calcium signalling in multicellular systems, starting from the known processes in single cells, and use it to gain insight into the functioning and possible dysfunctioning of calcium-mediated intercellular communication.