Differentiation-induction therapy with adipocytokine for cutaneous squamous cell carcinoma

脂肪细胞因子分化诱导治疗皮肤鳞状细胞癌

• 批准号: 19790791
• 负责人: INOUE Takuya
• 金额: $ 2.4万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790791/
• 关键词: 皮膚腫瘍学; 分化誘導療法; 皮膚癌; adiponectin; adionectin; adipocytokine

We have shown that subcutaneous adipocytes of rats facilitate the differentiation of squamous cell carcinoma cells of the skin in vitro. We hypothesized that adipocyte-derived cytokines have a promoting effect on differentiation of carcinoma cells. We examined the effect of adiponectin on squamous cell carcinoma cells of the skin and investigated the role of adipocytokine on the growth and differentiation of the cancer cells.

我们已经表明，大鼠皮下脂肪细胞促进了体外皮肤鳞状细胞癌细胞的分化。我们假设脂肪细胞衍生的细胞因子对癌细胞的分化有促进作用。我们检查了脂联素对皮肤鳞状细胞癌细胞的影响，并研究了脂肪细胞因子对癌细胞生长和分化的作用。