The relationship between the gene expression profile and the type of hearing impairment.

基因表达谱与听力障碍类型之间的关系。

• 批准号: 19791202
• 负责人: SUZUKI Nobuyoshi
• 金额: $ 2.28万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791202/
• 关键词: 高音障害型難聴; 老人性難聴; 遺伝子発現パターン; SAM; レーザーマイクロダイセクション; 高音障害型感音難聴; SAMマウス

Many hearing impairments are known to be caused by genetic factor. Heareditary hearing loss contributes to the various type of hearing impairments. However, little is known about what lead to such many different phenotypes. And now, it is generally accepted that the importance of the searching another responsible genes for auditory disturbance or the identification with the localization of transcription products. We hypothesized that the variety of phenotypes are caused by not only distribution of products but also the differences in the pattern of the gene expression. We attempted to identify the gene expression analysis in the cochlea by using Real-Time PCR with laser micro dissection system and the DNA microarray analysis with using the model mouse for age-related hearing impairment.

许多听力障碍是由遗传因素引起的。听力损失的类型有哪些？然而，人们对导致如此多不同表型的原因知之甚少。目前，寻找与听觉障碍相关的其他基因或通过转录产物的定位来鉴定听觉障碍的重要性已被普遍接受。我们推测，表型的多样性不仅是由产品的分布，但也在基因表达模式的差异。本研究采用激光显微切割系统实时荧光定量PCR技术和基因芯片技术，以老年性耳聋模型小鼠为研究对象，对老年性耳聋小鼠耳蜗组织基因表达进行了研究。

项目成果

SAMP1の内耳における遺伝子発現について

SAMP1在内耳中的基因表达

• 发表时间: 2008
• 作者: 上條篤;他;鈴木伸嘉
• 通讯作者: 鈴木伸嘉

Gene expression profiles in the cochlea of the senscence-accelerated mouse(SAM)

感知加速小鼠（SAM）耳蜗中的基因表达谱

• 发表时间: 2007
• 作者: 鈴木伸嘉;橋本繁成;森政之;樋口京一;宇佐美真一;鈴木 伸嘉
• 通讯作者: 鈴木 伸嘉