The relationship between the gene expression profile and the type of hearing impairment.

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Many hearing impairments are known to be caused by genetic factor. Heareditary hearing loss contributes to the various type of hearing impairments. However, little is known about what lead to such many different phenotypes. And now, it is generally accepted that the importance of the searching another responsible genes for auditory disturbance or the identification with the localization of transcription products. We hypothesized that the variety of phenotypes are caused by not only distribution of products but also the differences in the pattern of the gene expression. We attempted to identify the gene expression analysis in the cochlea by using Real-Time PCR with laser micro dissection system and the DNA microarray analysis with using the model mouse for age-related hearing impairment.