Relationship between mechanism of the reduction of the nasal polyp by the indomethacin and the laminin

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Both the immunoreactivity and mRNA of alpha1, beta1, gamma1, and gamma2 subunit of laminin were significantly detected in the nasal polyps in comparison with control normal sinus mucosa. The localization of gamma1 subunit of laminin expression predominantly coincided with thickened basement membrane. These results suggest that the up-regulation of laminin, especially gamma1 subunit of laminin, in human nasal polyps might be one of the most important cause of the development of nasal polyp. However, we did not able to identify a mechanism of the reduction of nasal polyps by the indomethacin.