Relationship between mechanism of the reduction of the nasal polyp by the indomethacin and the laminin

吲哚美辛缩小鼻息肉的机制与层粘连蛋白的关系

• 批准号: 19791248
• 负责人: UDAKA Tsuyoshi
• 金额: $ 2.3万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19791248/
• 关键词: 鼻茸; ラミニン; 細胞外マトリックス; 基底膜; 光顕免疫染色法; PCR; Western Blot; ラミニンγ1

Both the immunoreactivity and mRNA of alpha1, beta1, gamma1, and gamma2 subunit of laminin were significantly detected in the nasal polyps in comparison with control normal sinus mucosa. The localization of gamma1 subunit of laminin expression predominantly coincided with thickened basement membrane. These results suggest that the up-regulation of laminin, especially gamma1 subunit of laminin, in human nasal polyps might be one of the most important cause of the development of nasal polyp. However, we did not able to identify a mechanism of the reduction of nasal polyps by the indomethacin.

与正常鼻窦黏膜比较，鼻息肉组层粘连蛋白α 1、β 1、γ ma1、γ ma2亚基mRNA和免疫反应性均显著升高。层粘连蛋白γ - 1亚基的表达主要与基底膜增厚一致。这些结果提示，人鼻息肉中层粘连蛋白，尤其是层粘连蛋白γ - 1亚基的上调可能是鼻息肉发生的重要原因之一。然而，我们无法确定消炎痛减少鼻息肉的机制。