Relationship between mechanism of the reduction of the nasal polyp by the indomethacin and the laminin

与正常鼻窦黏膜比较，鼻息肉组层粘连蛋白α 1、β 1、γ ma1、γ ma2亚基mRNA和免疫反应性均显著升高。层粘连蛋白γ - 1亚基的表达主要与基底膜增厚一致。这些结果提示，人鼻息肉中层粘连蛋白，尤其是层粘连蛋白γ - 1亚基的上调可能是鼻息肉发生的重要原因之一。然而，我们无法确定消炎痛减少鼻息肉的机制。

Both the immunoreactivity and mRNA of alpha1, beta1, gamma1, and gamma2 subunit of laminin were significantly detected in the nasal polyps in comparison with control normal sinus mucosa. The localization of gamma1 subunit of laminin expression predominantly coincided with thickened basement membrane. These results suggest that the up-regulation of laminin, especially gamma1 subunit of laminin, in human nasal polyps might be one of the most important cause of the development of nasal polyp. However, we did not able to identify a mechanism of the reduction of nasal polyps by the indomethacin.