Research for the effects of toluene exposure on the development and sexual differentiation of the brain

甲苯暴露对大脑发育和性别分化影响的研究

• 批准号: 19681006
• 负责人: TSUKAHARA Shinji
• 金额: $ 13.73万
• 依托单位: National Institute for Environmental Studies
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19681006/
• 关键词: トルエン; 脳の性分化; テストステロン; 性的二型核; アポトーシス; 揮発性有機化合物; エストラジオール

We recently pay attention to the risk of the adverse effects of environmental chemical exposure on child health. This study was aimed to determine the effects of developmental exposure to toluene, a volatile organic compound widely used as an industrial solvent, on the sexual differentiation of the brain. As the results, it was found that exposure to toluene during developing period decreased blood testosterone levels of fetal male rats and the volume of the SDN-POA, a sexually dimorphic nucleus, of male rats in adulthood.

近年来，环境化学品暴露对儿童健康的不良影响引起了人们的关注。本研究旨在确定发育暴露于甲苯（一种广泛用作工业溶剂的挥发性有机化合物）对大脑性别分化的影响。结果发现，在发育期暴露于甲苯会降低雄性大鼠胎儿的血液睾酮水平和成年雄性大鼠SDN-POA（一种性二型核）的体积。

项目成果

Increased hippocampal mRNA expression of neuronal synaptic plasticity related genes in mice chronically exposed to toluene at a low-level human occupational-exposure.

在低水平人类职业暴露下长期接触甲苯的小鼠中，神经元突触可塑性相关基因的海马 mRNA 表达增加。

• 发表时间: 2007
• 期刊: Neurotoxicology 28・1
• 作者: Sohel Ahmed

発達期のトルエン曝露によるテストステロン分泌および脳内のアポトーシス細胞死への影響

发育过程中接触甲苯对大脑睾酮分泌和细胞凋亡的影响

• 发表时间: 2008
• 作者: 塚原伸治;黒田淑子;中島大介;影山志保;藤巻秀和
• 通讯作者: 藤巻秀和

Athymic nude mice are insensitive to low-leve toluene-induced up-regulation of memory-related gene expression in the hippocampus.

无胸腺裸鼠对低水平甲苯诱导的海马记忆相关基因表达上调不敏感。

• 发表时间: 2007
• 期刊: Neurotoxicology 28
• 作者: 中川剛志;横山利彦;Tin-Tin-Win-Shwe
• 通讯作者: Tin-Tin-Win-Shwe

Effects of developmental exposure to toluene on the sexual diffrentiation of the brain

发育期接触甲苯对大脑性别分化的影响

• 发表时间: 2008
• 作者: 中川剛志;横山利彦;Shinji Tiukahara
• 通讯作者: Shinji Tiukahara

Effects of exposure to toluene on steroidogenesis in testes and sromatization of testosterone in brain of male rats furing featal life

甲苯暴露对胎龄雄性大鼠睾丸类固醇生成和脑内睾酮sromatization的影响

• 发表时间: 2008
• 作者: 中川剛志;横山利彦;Shinji Tsukahara
• 通讯作者: Shinji Tsukahara