Prolonged effect of carnitine administration : Changes of energy production in carnitine-deficient mice

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In this study, I examined the prolonged effects of single carnitine administration on the energy expenditure of fasted carnitine-deficient juvenile visceral steatosis (jvs^<-/->) mice. The study was able to evaluate the in vivo long-chain fatty acid (LCFA) oxidation activity of the mice under various conditions by intravenously injecting [1-^<14>C]-palmitic acid and measuring the breath or expiratory ^<14>C-CO_2. Leptin, which stimulates the AMP-activated protein kinase (AMPK), increased in the plasma after a single carnitine administration in jvs^<-/-> mice.