Search for useful biomarkers in bone and soft tissue tumors using global expression analysis

使用全局表达分析寻找骨和软组织肿瘤中有用的生物标志物

• 批准号: 19591743
• 负责人: KAWAI Akira
• 金额: $ 2.91万
• 依托单位: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591743/
• 关键词: 骨軟部腫瘍; バイオマーカー; 網羅的発現解析; タンパク質; 遺伝子; 悪性骨軟部腫瘍; 二次元電気泳動

In the current study a number of novel prognostic factors and factors determining the biological characteristics of gastrointestinal stromal tumor (GIST), Ewing's sarcoma, and synovial sarcoma were identified. For GIST, a novel prognostic marker "pfetin" was identified on 2D-DIGE, and its usefulness was verified by performing immunostaining for samples from multiple facilities. As for Ewing's sarcoma, "nucleophosmin" was identified as a novel prognostic marker.

在当前的研究中，确定了许多新的预后因素和决定胃肠道间质瘤（GIST）、尤文氏肉瘤和滑膜肉瘤生物学特征的因素。对于 GIST，在 2D-DIGE 上鉴定出了一种新的预后标记物“pfetin”，并通过对多个设施的样本进行免疫染色验证了其有效性。对于尤文氏肉瘤，“核磷蛋白”被确定为一种新的预后标志物。

项目成果

Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics

• DOI: 10.1158/1078-0432.ccr-07-1478
• 发表时间: 2008-03-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Suehara, Yoshiyuki;Kondo, Tadashi;Hirohashi, Setsuo
• 通讯作者: Hirohashi, Setsuo

Nucleophosmin as a Candidate Prognostic Biomarker of Ewing's Sarcoma Revealed by Proteomics

• DOI: 10.1158/1078-0432.ccr-08-1913
• 发表时间: 2009-04-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Kikuta, Kazutaka;Tochigi, Naobumi;Kondo, Tadashi
• 通讯作者: Kondo, Tadashi

骨・軟部腫瘍に対する補助化学療法.

骨和软组织肿瘤的辅助化疗。

• 发表时间: 2008
• 期刊: 腫瘍内科 2(6)
• 作者: 小林英介;川井章.
• 通讯作者: 川井章.

全国骨・軟部腫瘍登録について

关于国家骨和软组织肿瘤登记处

• 发表时间: 2009
• 期刊: MB Orthop 22
• 作者: 宮武慎;遠山晴一;近藤英司;桂太郎;小野寺伸;安田和則;川井章
• 通讯作者: 川井章

Multiinstitutional phase II study of neoadjuvant chemotherapy for osteosarcoma (NECO study) in Japan: NECO-93J and NECO-95J

• DOI: 10.1007/s00776-009-1347-6
• 发表时间: 2009-07-01
• 期刊: JOURNAL OF ORTHOPAEDIC SCIENCE
• 影响因子: 1.7
• 作者: Iwamoto, Yukihide;Tanaka, Kazuhiro;Yamawaki, Shinya
• 通讯作者: Yamawaki, Shinya