Bio-physiological analysis of superior oblique palsy

通过分析先天性上级斜肌麻痹（SOP）患者ARIX、PHOX 2B和KIF 21 A 3个基因的核苷酸变化，ARIX 153 G>A多态性可能是先天性上级斜肌麻痹发生的遗传因素。通过头戴式摄像机测量系统测量静态眼球反滚，临床诊断的SOP患者同侧头倾斜时上斜视的绝对值不能直接评价SO肌的功能，同侧头倾斜时上斜视与直立位时上斜视的差值是一个较好的指标。SO肌肉大小不能解释SOP与MRI研究中Bielschowsky头部倾斜现象的变化，支持Bielschowsky头部倾斜现象对SO功能无特异性的主张。

The ARIX 153G>A polymorphism might be a genetic factor for the development of congenital superior oblique palsy by analyzing nucleotide changes in 3 genes, ARIX, PHOX2B, and KIF21A in congenital superior oblique palsy (SOP). By measuring static ocular counterrolling with aid of measuring system of head mounted video CCD camera, absolute value of the hypertropia on ipsilateral head tilt in clinically diagnosed SOP dose not directly assess the function in the SO muscle, the difference in hypertropia between ipsilateral head tilt and the upright position is a better indicator of SOP. SO muscle size does not account for the variation in Bielschowsky head tilt phenomenon in SOP with MRI study, supporting the proposition that the Bielschowsky head tilt phenomenon is nonspecific for SO function.