Cell dynamics in transition stage from crown to tooth root formation and effects of growth factors in development of Hertwig epithelial root sheath

Hertwig上皮根鞘发育过程中牙冠到牙根形成过渡阶段的细胞动力学及生长因子的影响

• 批准号: 19592128
• 负责人: FUJIWARA Naoki
• 金额: $ 2.91万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592128/
• 关键词: 歯の発生; 歯根形成; ヘルトヴィッヒ上皮鞘; 器官培養; EGF; サービカルループ; 上皮成長因子; GFP; 歯根形戌

臼歯の歯根形成にはヘルトヴィッヒ上皮鞘(HERS)が重要な役割を果たすことが知られているが、その中で理解が乏しいHERS発達のメカニズムについて今回検討した。我々は2つのオリジナルな器官培養系を用いて上皮成長因子epidermal growth factor、インスリン様成長因子insulin-like growth factor-Iが、それぞれ歯冠形成からHERS形成の移行時期、HERSの伸長・発達に重要な作用を示すことを明らかにした。

The roots of the molluscs were formed. The epithelial sheath (HERS) was important. The fruits were cut. They knew that they were not aware of the disease. They were not aware of the lack of HERS. We used the growth factor epidermal growth factor, the growth factor insulin-like growth factor-I, the crown formation phase of HERS and the important role of HERS in the organ culture system.

项目成果

The epithelial-mesenchymal interaction plays a role in the maintenance of the stem cell niche of mouse incisors via Fgf10 and Fgf9 signaling

上皮-间质相互作用通过 Fgf10 和 Fgf9 信号传导在维持小鼠门牙干细胞生态位中发挥作用

• 发表时间: 2008
• 期刊: The Open Biotechnology journal 2
• 作者: Tamaki Yokohama-Tamaki;Shibata S.,Wakisaka S.,Harada H
• 通讯作者: Shibata S.,Wakisaka S.,Harada H

Fgf-9 play a role for the maintenance of stem cell niche via Fgf-10 expression in the mouse incisors

Fgf-9 通过小鼠门牙中 Fgf-10 的表达在维持干细胞生态位中发挥作用

• 发表时间: 2007
• 作者: Tamaki Yokohama-Tamaki;Shibata S.,Wakisaka S.,Harada H;Tamaki Yokohama-Tamaki;田巻玉器,前田隆史,柴田俊一;田巻玉器;田巻玉器;田巻玉器;Yokohama-Tamaki Tamaki
• 通讯作者: Yokohama-Tamaki Tamaki