Study of a novel protein secretion system of Porphyromonas gingivalis

牙龈卟啉单胞菌新型蛋白分泌系统的研究

• 批准号: 19592135
• 负责人: SAIKI Keitarou
• 金额: $ 2.83万
• 依托单位: The Nippon Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592135/
• 关键词: 口腔細菌学; 蛋白分泌; ジンジパイン; 歯周病

A novel outer membrane protein Sov and a novel membrane protein PG27 were identified as essential factors for the secretion of gingipain protease virulence factors of Porphyromonas gingivalis. The C-terminal portion of Sov is exposed to the extracellular milieu and involved in the modulation of Sov function. These results suggest that gingipains are secreted via a novel protein secretion pathway, and that Sov and PG27 are promising targets for antiperiodontitis drug development.

发现一种新的外膜蛋白Sov和一种新的膜蛋白PG27是牙龈卟啉单胞菌分泌牙龈蛋白酶毒力因子的必需因子。Sov的c端部分暴露于细胞外环境并参与Sov功能的调节。这些结果表明牙周炎是通过一种新的蛋白分泌途径分泌的，Sov和PG27是抗牙周炎药物开发的有希望的靶点。