Development of DNA/chitosan/lipid complex multi-layer membrane for GTR, GBR

GTR、GBR用DNA/壳聚糖/脂质复合物多层膜的开发

• 批准号: 19592277
• 负责人: INOUE Yusuke
• 金额: $ 2.83万
• 依托单位: Fukuoka College of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592277/
• 关键词: 生体材料; DNA; キトサン; GTR; GBR; メンブレン

The characteristics of experimental multi-layer GTR or GBR membrane made from DNA, chitosan and amphiphilic lipid was investigated. And also the possibility of multi-layer formation on the DNA/chitosan/lipid complex film or GTR membrane on the market or titan plate was investigated. DNA/chitosan/lipid complex multilayer membrane showed antibacterial activity against Porphyromonas gingivalis and Staphyrococcus aureus, and antifungal activity against Candida albicans. The DNA/chitosan/lipid complex multilayer formed on the DNA/chitosan/lipid complex film or GTR membrane, and showed antibacterial activity and antifungal activity as DNA/chitosan/lipid complex multilayer membrane showed.

研究了由DNA、壳聚糖和两亲性脂类制成的实验多层膜的特性。并对市售DNA/壳聚糖/脂质复合膜或GTR膜或钛板上形成多层膜的可能性进行了研究。DNA/壳聚糖/脂质复合多层膜对牙龈卟啉单胞菌和金黄色葡萄球菌具有抗菌活性，对白色念珠菌具有抗真菌活性。DNA/壳聚糖/脂复合膜或GTR膜上形成了DNA/壳聚糖/脂复合膜多层膜，显示出抗菌和抗真菌活性。