Development of DNA/chitosan/lipid complex multi-layer membrane for GTR, GBR

GTR、GBR用DNA/壳聚糖/脂质复合物多层膜的开发

• 批准号: 19592277
• 负责人: INOUE Yusuke
• 金额: $ 2.83万
• 依托单位: Fukuoka College of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592277/
• 关键词: 生体材料; DNA; キトサン; GTR; GBR; メンブレン

The characteristics of experimental multi-layer GTR or GBR membrane made from DNA, chitosan and amphiphilic lipid was investigated. And also the possibility of multi-layer formation on the DNA/chitosan/lipid complex film or GTR membrane on the market or titan plate was investigated. DNA/chitosan/lipid complex multilayer membrane showed antibacterial activity against Porphyromonas gingivalis and Staphyrococcus aureus, and antifungal activity against Candida albicans. The DNA/chitosan/lipid complex multilayer formed on the DNA/chitosan/lipid complex film or GTR membrane, and showed antibacterial activity and antifungal activity as DNA/chitosan/lipid complex multilayer membrane showed.

研究了由DNA、壳聚糖和两亲性脂质制成的实验性多层GTR或GBR膜的特性。并对DNA/壳聚糖/脂质复合物膜、市售GTR膜或Titan板上形成多层膜的可能性进行了研究。DNA/壳聚糖/脂质复合物多层膜对牙龈卟啉单胞菌和金黄色葡萄球菌具有抗菌活性，对白色念珠菌具有抗真菌活性。在DNA/壳聚糖/脂质复合物膜或GTR膜上形成DNA/壳聚糖/脂质复合物多层膜，并显示出DNA/壳聚糖/脂质复合物多层膜所显示的抗菌活性和抗真菌活性。