Effects of opioids and supplementary analgesics on the accumbal catecholaminergic activity

阿片类药物和补充镇痛药对累积儿茶酚胺能活性的影响

• 批准号: 19592319
• 负责人: TAKADA Koji
• 金额: $ 2.91万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592319/
• 关键词: カテコラミン; 大脳基底核; 麻薬性鎮痛薬; 鎮痛補助薬; 口腔ジスキネジア; ドパミン; 線条体; 脳微小透析法; SKF38393; dexamphetamine; reserpine; α-methl-p-trosine; ラット; ノルアドレナリン; β受容体; NA取り込み阻害薬; reboxetine; 側坐核; endomorphin-1; endomorphin-2; GABA; GABA_A受容体

Dopaminergic neurons, which arise in the ventral tegmental area terminate among others in the nucleus accumbens. The detailed mechanisms of rewarding effects of opioids remain unclear, but the phanmaco-behavioural studies suggest that enhance of accumbal dopaminergic activity plays a significant role. Therefore, in the present study, we investigated the mechanisms of the increase of accumbal dopamine efflux in freely moving rats, using the in vivo brain microdialysis technique。 We also studied the noradrenaline-dopamine interaction in the nucleus accumbens and the intracellular origin of extracellulary released striatal dopamine.

产生于腹侧被盖区的多巴胺能神经元终止于伏隔核。阿片类药物奖励作用的详细机制尚不清楚，但药物行为研究表明，累积多巴胺能活性的增强起着重要作用。因此，在本研究中，我们利用体内脑微透析技术，研究了自由活动大鼠伏隔多巴胺流出增加的机制。我们还研究了伏隔核中去甲肾上腺素-多巴胺的相互作用以及细胞外释放的纹状体多巴胺的细胞内来源。