The role of cholinergic neurons on the manifestation and retention of experimental neuropathic pain model in mice
The role of cholinergic neurons on the manifestation and retention of experimental neuropathic pain model in mice
批准号:
19603012
负责人:
ABE Kenji
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
マウスの坐骨神経結紮による神経因性疼痛モデルの探索において,腓腹神経のみの単独結紮により明らかな疼痛閾値の低下が生じることを明らかにした。また,本モデルにおけるホルマリン誘発疼痛に対して,コリン作動薬の側脳室内投与は有意な鎮痛作用を発現した。この鎮痛作用は,ムスカリンM1およびM3受容体拮抗薬の前投与により一部抑制されたが,ホルマリン疼痛反応第II相に対する鎮痛作用には明らかな変化は生じなかった。
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