Comparative pathological study on H5N1 infection between humans and animals

人与动物H5N1感染的比较病理学研究

• 批准号: 21590449
• 负责人: ABE Kenji
• 金额: $ 2.91万
• 依托单位: National Institute of Infectious Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590449/
• 关键词: インフルエンザ; H5N1; 比較病理; 感染動物; 国際協力; 分子疫学; 国際研究; H1N1

We investigated autopsy cases of tigers and cats infected with H5N1.The animals had eaten fresh chicken or dead pigeon carcass infected with H5N1 and died caused by high fever and severe respiratory disorder. At necropsy, infected animals showed severe hemorrhagic lesion in a systemic organ. H5N1 related antigens was also detected in brain, lung and liver by an immunohistochemical method. Furthermore, a viral gene was isolated from lung tissue in infected animals and its showed high similarity to H5N1 isolated from a human patient in Thailand.

我们调查了H5N1感染的老虎和猫的尸检病例，这些动物食用了感染H5N1的新鲜鸡肉或死鸽子尸体，并因高热和严重的呼吸系统疾病而死亡。尸检时，感染动物的全身器官出现严重出血性病变。免疫组化法检测脑、肺、肝组织中H5N1相关抗原。此外，从受感染动物的肺组织中分离出一种病毒基因，该基因与从泰国一名人类患者中分离出的H5N1病毒高度相似。

项目成果

Molecular-based epidemiology and pathology of hepatitis B virus infection

乙型肝炎病毒感染的分子流行病学和病理学

• 发表时间: 2010
• 作者: Shi M;Adachi Y;他8人2番目;Kenji Abe
• 通讯作者: Kenji Abe

Presence of hepatitis C virus RNA by nested polymerase chain reaction in plasma-derived hepatitis B vaccine non-responders

通过巢式聚合酶链反应测定血浆源性乙型肝炎疫苗无反应者中丙型肝炎病毒 RNA 的存在

• 发表时间: 2010
• 期刊: Myanmar Health Sciences Research Journal
• 作者: Moh Moh Htun;Khin Pyone Kyi;Khin May Oo;Myo Khin;Win Maw Tun;San San Oo;Khin Ohnmar Lwin;Kenji Abe
• 通讯作者: Kenji Abe

Hepatitis B and C in Asia

亚洲的乙型和丙型肝炎

• 发表时间: 2011
• 作者: Kumagai T;Shimogawara R;Ohmae H;Wang TP;Lu SH;Chen R;Wen LY;Ohta N;Kenji Abe
• 通讯作者: Kenji Abe

Invited lecture=Hepatitis C in experimentally infected chimpanzees comparison with hepatitis B.

特邀讲座=实验感染黑猩猩中的丙型肝炎与乙型肝炎的比较。

• 发表时间: 2010
• 作者: 盖志博;伊藤俊治;谷島裕之;上谷光作;伊藤正孝;村垣泰光;Kenji Abe
• 通讯作者: Kenji Abe

Stem cell origin of liver cancers in Asian children

亚洲儿童肝癌的干细胞起源

• 发表时间: 2009
• 作者: Swan N. Thung;Tung Thanh Tran;Phuc Le Hoang;Ja June Jang;Young Nyun Park;Kenji Abe
• 通讯作者: Kenji Abe