Comparative pathological study on H5N1 infection between humans and animals

我们调查了感染H5N1病毒的老虎和猫的尸检案例，这些动物曾吃过感染H5N1的新鲜鸡肉或死鸽子身体，并因高烧和严重呼吸系统疾病而死亡。在尸检中，感染的动物在系统器官中显示严重的出血性损害。免疫组织化学方法检测H5N1相关抗原在脑、肺、肝组织中的表达。此外，从感染动物的肺组织中分离到一种病毒基因，它与从泰国一名人类患者身上分离的H5N1病毒有很高的相似性。

We investigated autopsy cases of tigers and cats infected with H5N1.The animals had eaten fresh chicken or dead pigeon carcass infected with H5N1 and died caused by high fever and severe respiratory disorder. At necropsy, infected animals showed severe hemorrhagic lesion in a systemic organ. H5N1 related antigens was also detected in brain, lung and liver by an immunohistochemical method. Furthermore, a viral gene was isolated from lung tissue in infected animals and its showed high similarity to H5N1 isolated from a human patient in Thailand.