New approach for health maintenanceand disease control by modification of inhaled air composition

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Recent studies demonstrated that molecular hydrogen functions as a novel antioxidant. We examined whether molecular hydrogen attenuates disease progression using model animals such as Parkinson disease, allergic reaction, liver damage by bacterial toxin and others and found that molecular hydrogen is effective for a wide variety of diseases including inflammatory diseases in which oxidative stress is not a major cause of the pathogenesis. We also found that hydrogen slightly extended the lifespan in C. elegans under 60% oxygen condition. DNA microarray analysis revealed that short-lasting hydrogen exposure by hydrogen-rich water induced more significant change in gene expression in the liver tissue. These results suggest that intermittent administration of hydrogen in living environment may serve as a new approach for health maintenance.